BRD-K77987382_Mebendazole_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

163 genes differentially expressed following the BRD-K77987382_Mebendazole_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADORA2B adenosine A2b receptor
AIM1 absent in melanoma 1
ALB albumin
ALOX5 arachidonate 5-lipoxygenase
ANXA1 annexin A1
AREG amphiregulin
ARG2 arginase 2
CAPN2 calpain 2, (m/II) large subunit
CAV1 caveolin 1, caveolae protein, 22kDa
CCND2 cyclin D2
CD44 CD44 molecule (Indian blood group)
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CLEC5A C-type lectin domain family 5, member A
CSRP1 cysteine and glycine-rich protein 1
CYR61 cysteine-rich, angiogenic inducer, 61
DPYSL3 dihydropyrimidinase-like 3
DUSP4 dual specificity phosphatase 4
EPAS1 endothelial PAS domain protein 1
EREG epiregulin
FAM129A family with sequence similarity 129, member A
FAM69A family with sequence similarity 69, member A
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FXYD5 FXYD domain containing ion transport regulator 5
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GLIPR1 GLI pathogenesis-related 1
HOPX HOP homeobox
HPCAL1 hippocalcin-like 1
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IGHM immunoglobulin heavy constant mu
IPO13 importin 13
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGB5 integrin, beta 5
JAG1 jagged 1
JUN jun proto-oncogene
LDHB lactate dehydrogenase B
LMO3 LIM domain only 3 (rhombotin-like 2)
LPAR6 lysophosphatidic acid receptor 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MT1X metallothionein 1X
NEB nebulin
NPTX2 neuronal pentraxin II
NT5E 5'-nucleotidase, ecto (CD73)
NTS neurotensin
P3H2 prolyl 3-hydroxylase 2
PDLIM3 PDZ and LIM domain 3
PEA15 phosphoprotein enriched in astrocytes 15
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIEZO1 piezo-type mechanosensitive ion channel component 1
PLN phospholamban
PPARG peroxisome proliferator-activated receptor gamma
PRUNE2 prune homolog 2 (Drosophila)
RAI14 retinoic acid induced 14
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RND3 Rho family GTPase 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SH2B3 SH2B adaptor protein 3
SHB Src homology 2 domain containing adaptor protein B
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPRR3 small proline-rich protein 3
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
TIMP1 TIMP metallopeptidase inhibitor 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPM2 tropomyosin 2 (beta)
TRHDE thyrotropin-releasing hormone degrading enzyme
TRIB2 tribbles pseudokinase 2
TRIM2 tripartite motif containing 2
TUBB2A tubulin, beta 2A class IIa
VEGFA vascular endothelial growth factor A
WT1 Wilms tumor 1

decreased expression

Symbol Name
AGR2 anterior gradient 2
AKR1C3 aldo-keto reductase family 1, member C3
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ARMCX3 armadillo repeat containing, X-linked 3
ARMT1 acidic residue methyltransferase 1
B3GNT1
BST2 bone marrow stromal cell antigen 2
CA12 carbonic anhydrase XII
CDC42 cell division cycle 42
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CIRBP cold inducible RNA binding protein
CLU clusterin
CXCL12 chemokine (C-X-C motif) ligand 12
CYFIP2 cytoplasmic FMR1 interacting protein 2
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DLD dihydrolipoamide dehydrogenase
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EBP emopamil binding protein (sterol isomerase)
EED embryonic ectoderm development
EIF5A eukaryotic translation initiation factor 5A
ESR1 estrogen receptor 1
FAM134B family with sequence similarity 134, member B
FAM63A family with sequence similarity 63, member A
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GATA3 GATA binding protein 3
GCH1 GTP cyclohydrolase 1
GMFB glia maturation factor, beta
GSTM3 glutathione S-transferase mu 3 (brain)
HLTF helicase-like transcription factor
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IRX5 iroquois homeobox 5
KRT19 keratin 19, type I
LAPTM4B lysosomal protein transmembrane 4 beta
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MBP myelin basic protein
MRPS30 mitochondrial ribosomal protein S30
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUC1 mucin 1, cell surface associated
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NRCAM neuronal cell adhesion molecule
PECR peroxisomal trans-2-enoyl-CoA reductase
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRKCD protein kinase C, delta
PTGES prostaglandin E synthase
QDPR quinoid dihydropteridine reductase
RBBP4 retinoblastoma binding protein 4
RPS27L ribosomal protein S27-like
SEPHS2 selenophosphate synthetase 2
SET SET nuclear proto-oncogene
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLIT2 slit homolog 2 (Drosophila)
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
STC2 stanniocalcin 2
TFF3 trefoil factor 3 (intestinal)
TMBIM6 transmembrane BAX inhibitor motif containing 6
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOP2A topoisomerase (DNA) II alpha 170kDa
TPBG trophoblast glycoprotein
TPD52L1 tumor protein D52-like 1
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBL3 ubiquitin-like 3
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGCG UDP-glucose ceramide glucosyltransferase
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZWINT ZW10 interacting kinetochore protein