BRD-K77987382_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

100 genes differentially expressed following the BRD-K77987382_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ACOT9 acyl-CoA thioesterase 9
AHNAK AHNAK nucleoprotein
ANXA1 annexin A1
AREG amphiregulin
CAB39 calcium binding protein 39
CD58 CD58 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
CYTH1 cytohesin 1
DUSP1 dual specificity phosphatase 1
DUSP14 dual specificity phosphatase 14
DUSP3 dual specificity phosphatase 3
EDN1 endothelin 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGFR epidermal growth factor receptor
EMP1 epithelial membrane protein 1
EPHA2 EPH receptor A2
EZR ezrin
F11R F11 receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
FBN2 fibrillin 2
FGFR3 fibroblast growth factor receptor 3
FHL2 four and a half LIM domains 2
FILIP1L filamin A interacting protein 1-like
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GOLM1 golgi membrane protein 1
HBEGF heparin-binding EGF-like growth factor
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
ILK integrin-linked kinase
JUN jun proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT7 keratin 7, type II
MACF1 microtubule-actin crosslinking factor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR22HG MIR22 host gene
MSLN mesothelin
MXRA7 matrix-remodelling associated 7
MYL9 myosin, light chain 9, regulatory
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
PALLD palladin, cytoskeletal associated protein
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDGFA platelet-derived growth factor alpha polypeptide
PEA15 phosphoprotein enriched in astrocytes 15
PLAU plasminogen activator, urokinase
PPARD peroxisome proliferator-activated receptor delta
PRSS23 protease, serine, 23
RGS5 regulator of G-protein signaling 5
RRAD Ras-related associated with diabetes
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SEC14L1 SEC14-like 1 (S. cerevisiae)
SFN stratifin
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SORBS2 sorbin and SH3 domain containing 2
SPATS2L spermatogenesis associated, serine-rich 2-like
SPTAN1 spectrin, alpha, non-erythrocytic 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
TACC1 transforming, acidic coiled-coil containing protein 1
TACSTD2 tumor-associated calcium signal transducer 2
TAGLN transgelin
TJP1 tight junction protein 1
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPM1 tropomyosin 1 (alpha)
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
VCL vinculin
WIPF2 WAS/WASL interacting protein family, member 2
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ASS1 argininosuccinate synthase 1
BCL6 B-cell CLL/lymphoma 6
C3 complement component 3
CA12 carbonic anhydrase XII
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL6A3 collagen, type VI, alpha 3
CYBA cytochrome b-245, alpha polypeptide
EIF1AX eukaryotic translation initiation factor 1A, X-linked
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
GPX2 glutathione peroxidase 2
HOXA10 homeobox A10
HOXA5 homeobox A5
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
MAOB monoamine oxidase B
NID2 nidogen 2 (osteonidogen)
NRIP1 nuclear receptor interacting protein 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SLC39A8 solute carrier family 39 (zinc transporter), member 8