BRD-K77987382_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

157 genes differentially expressed following the BRD-K77987382_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM9 ADAM metallopeptidase domain 9
ANXA3 annexin A3
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF3 activating transcription factor 3
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BCL2A1 BCL2-related protein A1
BICD2 bicaudal D homolog 2 (Drosophila)
BTG2 BTG family, member 2
BTG3 BTG family, member 3
CADM1 cell adhesion molecule 1
CASP7 caspase 7, apoptosis-related cysteine peptidase
CD9 CD9 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CHMP2B charged multivesicular body protein 2B
CLEC2B C-type lectin domain family 2, member B
CLEC5A C-type lectin domain family 5, member A
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP3 epithelial membrane protein 3
ENO2 enolase 2 (gamma, neuronal)
EPN2 epsin 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM129A family with sequence similarity 129, member A
FOSL1 FOS-like antigen 1
FRMD4B FERM domain containing 4B
G0S2 G0/G1 switch 2
GEM GTP binding protein overexpressed in skeletal muscle
GRB10 growth factor receptor-bound protein 10
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HBEGF heparin-binding EGF-like growth factor
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER3 immediate early response 3
IL4R interleukin 4 receptor
INHBA inhibin, beta A
INPP1 inositol polyphosphate-1-phosphatase
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JUNB jun B proto-oncogene
KDM6B lysine (K)-specific demethylase 6B
KLF6 Kruppel-like factor 6
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
LAMC2 laminin, gamma 2
LDLR low density lipoprotein receptor
LRP10 low density lipoprotein receptor-related protein 10
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MAP2K3 mitogen-activated protein kinase kinase 3
MCL1 myeloid cell leukemia 1
MFSD10 major facilitator superfamily domain containing 10
MICALL1 MICAL-like 1
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
NDRG1 N-myc downstream regulated 1
NT5E 5'-nucleotidase, ecto (CD73)
PALLD palladin, cytoskeletal associated protein
PANX1 pannexin 1
PEA15 phosphoprotein enriched in astrocytes 15
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PLEK2 pleckstrin 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRNP prion protein
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PTHLH parathyroid hormone-like hormone
PTRF polymerase I and transcript release factor
RAB22A RAB22A, member RAS oncogene family
RALB v-ral simian leukemia viral oncogene homolog B
RND3 Rho family GTPase 3
S100A11 S100 calcium binding protein A11
S100A2 S100 calcium binding protein A2
S100A6 S100 calcium binding protein A6
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOX4 SRY (sex determining region Y)-box 4
SPRR1B small proline-rich protein 1B
SPRR3 small proline-rich protein 3
STX3 syntaxin 3
SYNJ2 synaptojanin 2
TACSTD2 tumor-associated calcium signal transducer 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TOMM34 translocase of outer mitochondrial membrane 34
TRIB1 tribbles pseudokinase 1
TUBB2A tubulin, beta 2A class IIa
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UPP1 uridine phosphorylase 1
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
AKAP7 A kinase (PRKA) anchor protein 7
AKR1C3 aldo-keto reductase family 1, member C3
B3GNT1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CECR1 cat eye syndrome chromosome region, candidate 1
CFB complement factor B
CHN2 chimerin 2
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
EHD3 EH-domain containing 3
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM134B family with sequence similarity 134, member B
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GJA1 gap junction protein, alpha 1, 43kDa
GPRC5B G protein-coupled receptor, class C, group 5, member B
HMGN3 high mobility group nucleosomal binding domain 3
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGHD immunoglobulin heavy constant delta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
NID2 nidogen 2 (osteonidogen)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCSK1 proprotein convertase subtilisin/kexin type 1
PDZK1 PDZ domain containing 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PNMA2 paraneoplastic Ma antigen 2
POU2AF1 POU class 2 associating factor 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PSIP1 PC4 and SFRS1 interacting protein 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PYCARD PYD and CARD domain containing
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SORBS3 sorbin and SH3 domain containing 3
SOX11 SRY (sex determining region Y)-box 11
STAT1 signal transducer and activator of transcription 1, 91kDa
SYBU syntabulin (syntaxin-interacting)
TARBP1 TAR (HIV-1) RNA binding protein 1
TLR4 toll-like receptor 4
TSPAN8 tetraspanin 8