BRD-K77908580_entinostat_PC3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

116 genes differentially expressed following the BRD-K77908580_entinostat_PC3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ACKR3 atypical chemokine receptor 3
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
APOD apolipoprotein D
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
BASP1 brain abundant, membrane attached signal protein 1
CCDC92 coiled-coil domain containing 92
CCNG2 cyclin G2
CD24 CD24 molecule
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSRP1 cysteine and glycine-rich protein 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP6 dual specificity phosphatase 6
E2F2 E2F transcription factor 2
EDN3 endothelin 3
EIF5A eukaryotic translation initiation factor 5A
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
EPHA3 EPH receptor A3
EXOSC4 exosome component 4
FGFR1 fibroblast growth factor receptor 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GLIPR1 GLI pathogenesis-related 1
GNLY granulysin
GPRC5A G protein-coupled receptor, class C, group 5, member A
HMOX1 heme oxygenase 1
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
ISG15 ISG15 ubiquitin-like modifier
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLF10 Kruppel-like factor 10
KRT18 keratin 18, type I
KRT7 keratin 7, type II
KRT8 keratin 8, type II
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LDLR low density lipoprotein receptor
MAP1B microtubule-associated protein 1B
MMD monocyte to macrophage differentiation-associated
MME membrane metallo-endopeptidase
MT1F metallothionein 1F
NAMPT nicotinamide phosphoribosyltransferase
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFA platelet-derived growth factor alpha polypeptide
PFKM phosphofructokinase, muscle
PHLDA1 pleckstrin homology-like domain, family A, member 1
PI3 peptidase inhibitor 3, skin-derived
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PTN pleiotrophin
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB29 RAB29, member RAS oncogene family
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RBM47 RNA binding motif protein 47
RBP1 retinol binding protein 1, cellular
RTN2 reticulon 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SIK1 salt-inducible kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SOX4 SRY (sex determining region Y)-box 4
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SYT1 synaptotagmin I
TAGLN2 transgelin 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TP53BP2 tumor protein p53 binding protein 2
TSPAN13 tetraspanin 13
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
AKAP8 A kinase (PRKA) anchor protein 8
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALDOA aldolase A, fructose-bisphosphate
BGN biglycan
BNC2 basonuclin 2
BRD4 bromodomain containing 4
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL2A1 collagen, type II, alpha 1
COL5A1 collagen, type V, alpha 1
COMP cartilage oligomeric matrix protein
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CTSH cathepsin H
DMD dystrophin
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
FGFR3 fibroblast growth factor receptor 3
HOXC10 homeobox C10
IGKV4-1 immunoglobulin kappa variable 4-1
LTF lactotransferrin
MECOM MDS1 and EVI1 complex locus
MYCBP MYC binding protein
NCOR1 nuclear receptor corepressor 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
PDLIM1 PDZ and LIM domain 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
THAP11 THAP domain containing 11
TRIM29 tripartite motif containing 29
TSPYL5 TSPY-like 5
VGLL4 vestigial-like family member 4