BRD-K77908580_entinostat_HEPG2_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

82 genes differentially expressed following the BRD-K77908580_entinostat_HEPG2_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ANXA3 annexin A3
AREG amphiregulin
CCNL2 cyclin L2
CD36 CD36 molecule (thrombospondin receptor)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
CORO1A coronin, actin binding protein, 1A
CPD carboxypeptidase D
CST1 cystatin SN
CTSC cathepsin C
CTSV cathepsin V
DSG1 desmoglein 1
EGR2 early growth response 2
EGR3 early growth response 3
ENO1 enolase 1, (alpha)
FSCN1 fascin actin-bundling protein 1
GEM GTP binding protein overexpressed in skeletal muscle
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GSN gelsolin
GSTM3 glutathione S-transferase mu 3 (brain)
HOPX HOP homeobox
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGFBP4 insulin-like growth factor binding protein 4
ISG15 ISG15 ubiquitin-like modifier
ISOC1 isochorismatase domain containing 1
LGALS1 lectin, galactoside-binding, soluble, 1
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NR4A2 nuclear receptor subfamily 4, group A, member 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
S100A6 S100 calcium binding protein A6
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIRT3 sirtuin 3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TIMP1 TIMP metallopeptidase inhibitor 1
TM4SF1 transmembrane 4 L six family member 1
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
VDAC1 voltage-dependent anion channel 1
WWTR1 WW domain containing transcription regulator 1

decreased expression

Symbol Name
ACOX2 acyl-CoA oxidase 2, branched chain
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ANPEP alanyl (membrane) aminopeptidase
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
CREG1 cellular repressor of E1A-stimulated genes 1
CSTA cystatin A (stefin A)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IPO13 importin 13
ITGB1BP1 integrin beta 1 binding protein 1
KRT13 keratin 13, type I
LOC100505650 uncharacterized LOC100505650
MECOM MDS1 and EVI1 complex locus
METTL7A methyltransferase like 7A
MSLN mesothelin
MUC16 mucin 16, cell surface associated
PNMA2 paraneoplastic Ma antigen 2
PRAME preferentially expressed antigen in melanoma
PRUNE2 prune homolog 2 (Drosophila)
PXMP2 peroxisomal membrane protein 2, 22kDa
SORBS2 sorbin and SH3 domain containing 2
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon