BRD-K77908580_entinostat_HCC515_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

82 genes differentially expressed following the BRD-K77908580_entinostat_HCC515_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA1 annexin A1
C10ORF10 chromosome 10 open reading frame 10
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CBR1 carbonyl reductase 1
CDCP1 CUB domain containing protein 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLEC2B C-type lectin domain family 2, member B
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
CRABP2 cellular retinoic acid binding protein 2
DKK2 dickkopf WNT signaling pathway inhibitor 2
EFNB2 ephrin-B2
EMP1 epithelial membrane protein 1
EPS8 epidermal growth factor receptor pathway substrate 8
FKBP1B FK506 binding protein 1B, 12.6 kDa
FZD6 frizzled class receptor 6
FZD7 frizzled class receptor 7
GPRC5A G protein-coupled receptor, class C, group 5, member A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HOXA10 homeobox A10
HPRT1 hypoxanthine phosphoribosyltransferase 1
IER3 immediate early response 3
ITGB5 integrin, beta 5
ITM2A integral membrane protein 2A
KRT6B keratin 6B, type II
LHFPL2 lipoma HMGIC fusion partner-like 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MXRA5 matrix-remodelling associated 5
NT5E 5'-nucleotidase, ecto (CD73)
PHLDA2 pleckstrin homology-like domain, family A, member 2
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PRAF2 PRA1 domain family, member 2
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RGS2 regulator of G-protein signaling 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100P S100 calcium binding protein P
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SOX11 SRY (sex determining region Y)-box 11
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
STXBP1 syntaxin binding protein 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TMEM45A transmembrane protein 45A
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TPBG trophoblast glycoprotein
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADCK3 aarF domain containing kinase 3
C7 complement component 7
CA12 carbonic anhydrase XII
CCND2 cyclin D2
CLU clusterin
DACH1 dachshund family transcription factor 1
FGFR3 fibroblast growth factor receptor 3
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
JADE2 jade family PHD finger 2
KIAA0101 KIAA0101
LCN2 lipocalin 2
LEF1 lymphoid enhancer-binding factor 1
LYZ lysozyme
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MSLN mesothelin
MYO5C myosin VC
RELN reelin
RPS4Y1 ribosomal protein S4, Y-linked 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TPM4 tropomyosin 4
WDR7 WD repeat domain 7
WT1 Wilms tumor 1