BRD-K77908580_entinostat_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

175 genes differentially expressed following the BRD-K77908580_entinostat_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADGRG2 adhesion G protein-coupled receptor G2
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKAP12 A kinase (PRKA) anchor protein 12
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ARHGAP29 Rho GTPase activating protein 29
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARL4C ADP-ribosylation factor-like 4C
ASPN asporin
ATF3 activating transcription factor 3
BAMBI BMP and activin membrane-bound inhibitor
BCL6 B-cell CLL/lymphoma 6
BTG1 B-cell translocation gene 1, anti-proliferative
CCNG2 cyclin G2
CD52 CD52 molecule
CDC42 cell division cycle 42
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLC Charcot-Leyden crystal galectin
COL11A1 collagen, type XI, alpha 1
CPD carboxypeptidase D
CXADR coxsackie virus and adenovirus receptor
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DACH1 dachshund family transcription factor 1
DDIT4 DNA-damage-inducible transcript 4
DHRS7 dehydrogenase/reductase (SDR family) member 7
DPP4 dipeptidyl-peptidase 4
DSG2 desmoglein 2
EDNRB endothelin receptor type B
EHBP1 EH domain binding protein 1
EMX2 empty spiracles homeobox 2
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPS8 epidermal growth factor receptor pathway substrate 8
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAM107A family with sequence similarity 107, member A
FBLN1 fibulin 1
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FYN FYN proto-oncogene, Src family tyrosine kinase
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GPX3 glutathione peroxidase 3
HEBP1 heme binding protein 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BK histone cluster 1, H2bk
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HPGDS hematopoietic prostaglandin D synthase
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IER3 immediate early response 3
IL13RA2 interleukin 13 receptor, alpha 2
IL17RB interleukin 17 receptor B
JAG1 jagged 1
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KIAA0040 KIAA0040
KLF9 Kruppel-like factor 9
KRT23 keratin 23, type I
L1CAM L1 cell adhesion molecule
LBH limb bud and heart development
LEPR leptin receptor
LGMN legumain
LIPA lipase A, lysosomal acid, cholesterol esterase
LTBP1 latent transforming growth factor beta binding protein 1
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MFAP4 microfibrillar-associated protein 4
MMD monocyte to macrophage differentiation-associated
NFIL3 nuclear factor, interleukin 3 regulated
NPC1 Niemann-Pick disease, type C1
NR2F1 nuclear receptor subfamily 2, group F, member 1
OSR2 odd-skipped related transciption factor 2
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PEG10 paternally expressed 10
PHGDH phosphoglycerate dehydrogenase
PLIN2 perilipin 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PMP22 peripheral myelin protein 22
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
RAB31 RAB31, member RAS oncogene family
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RGS2 regulator of G-protein signaling 2
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RTN2 reticulon 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERTAD2 SERTA domain containing 2
SGCE sarcoglycan, epsilon
SKAP2 src kinase associated phosphoprotein 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A1 solute carrier family 38, member 1
SORBS1 sorbin and SH3 domain containing 1
SOX9 SRY (sex determining region Y)-box 9
SPON1 spondin 1, extracellular matrix protein
SPP1 secreted phosphoprotein 1
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STOM stomatin
STXBP1 syntaxin binding protein 1
TGFA transforming growth factor, alpha
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNIK TRAF2 and NCK interacting kinase
TNNT1 troponin T type 1 (skeletal, slow)
TOB1 transducer of ERBB2, 1
TPD52L1 tumor protein D52-like 1
TSPAN13 tetraspanin 13
TUBB2B tubulin, beta 2B class IIb
TXNRD1 thioredoxin reductase 1
VAT1 vesicle amine transport 1
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ALCAM activated leukocyte cell adhesion molecule
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
AUTS2 autism susceptibility candidate 2
CBR3 carbonyl reductase 3
CCDC92 coiled-coil domain containing 92
CCNA2 cyclin A2
CCNE2 cyclin E2
CRYAB crystallin, alpha B
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
DLX2 distal-less homeobox 2
DOCK10 dedicator of cytokinesis 10
EFS embryonal Fyn-associated substrate
EGF epidermal growth factor
ELF5 E74-like factor 5 (ets domain transcription factor)
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
GALC galactosylceramidase
GREB1 growth regulation by estrogen in breast cancer 1
HSPA8 heat shock 70kDa protein 8
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
IGL immunoglobulin lambda locus
ILF3 interleukin enhancer binding factor 3, 90kDa
ITGA6 integrin, alpha 6
JCHAIN joining chain of multimeric IgA and IgM
KRT16 keratin 16, type I
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LCN2 lipocalin 2
LMNB1 lamin B1
LRRC41 leucine rich repeat containing 41
MBNL2 muscleblind-like splicing regulator 2
MCM7 minichromosome maintenance complex component 7
MOK MOK protein kinase
PDZK1IP1 PDZK1 interacting protein 1
PKP1 plakophilin 1
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
PPIC peptidylprolyl isomerase C (cyclophilin C)
PPIF peptidylprolyl isomerase F
PTS 6-pyruvoyltetrahydropterin synthase
RBM3 RNA binding motif (RNP1, RRM) protein 3
RRM2 ribonucleotide reductase M2
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
SELL selectin L
SFRP1 secreted frizzled-related protein 1
SHCBP1 SHC SH2-domain binding protein 1
TLE4 transducin-like enhancer of split 4
TOR1A torsin family 1, member A (torsin A)
UBXN8 UBX domain protein 8