BRD-K77908580_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

119 genes differentially expressed following the BRD-K77908580_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM10 ADAM metallopeptidase domain 10
ADGRE5 adhesion G protein-coupled receptor E5
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AREG amphiregulin
ATF3 activating transcription factor 3
C3 complement component 3
CA11 carbonic anhydrase XI
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRDL1 chordin-like 1
CLDN3 claudin 3
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COLEC12 collectin sub-family member 12
DDR2 discoidin domain receptor tyrosine kinase 2
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DHRS3 dehydrogenase/reductase (SDR family) member 3
DPYSL3 dihydropyrimidinase-like 3
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ELOVL5 ELOVL fatty acid elongase 5
EMP1 epithelial membrane protein 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EPS8 epidermal growth factor receptor pathway substrate 8
FAM13A family with sequence similarity 13, member A
FOXO4 forkhead box O4
FXYD5 FXYD domain containing ion transport regulator 5
GLRX glutaredoxin (thioltransferase)
GSDMB gasdermin B
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2BK histone cluster 1, H2bk
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IER3 immediate early response 3
IGF1 insulin-like growth factor 1 (somatomedin C)
ITGA6 integrin, alpha 6
KRT18 keratin 18, type I
KRT19 keratin 19, type I
LEF1 lymphoid enhancer-binding factor 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LMO3 LIM domain only 3 (rhombotin-like 2)
LOXL2 lysyl oxidase-like 2
LXN latexin
MLPH melanophilin
MSN moesin
MUC1 mucin 1, cell surface associated
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NELL2 NEL-like 2 (chicken)
NTS neurotensin
PBX1 pre-B-cell leukemia homeobox 1
PCP4 Purkinje cell protein 4
PDE8B phosphodiesterase 8B
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PON2 paraoxonase 2
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKD1 protein kinase D1
QPCT glutaminyl-peptide cyclotransferase
RBP4 retinol binding protein 4, plasma
RGCC regulator of cell cycle
RGS10 regulator of G-protein signaling 10
RGS2 regulator of G-protein signaling 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SELENBP1 selenium binding protein 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPON1 spondin 1, extracellular matrix protein
STEAP1 six transmembrane epithelial antigen of the prostate 1
SYT1 synaptotagmin I
TFF3 trefoil factor 3 (intestinal)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPD52L1 tumor protein D52-like 1
TRIM2 tripartite motif containing 2
TSC22D1 TSC22 domain family, member 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VCAN versican
VIM vimentin
VTCN1 V-set domain containing T cell activation inhibitor 1
WNT5A wingless-type MMTV integration site family, member 5A

decreased expression

Symbol Name
CDC25A cell division cycle 25A
CLTB clathrin, light chain B
COL6A1 collagen, type VI, alpha 1
CST3 cystatin C
CSTA cystatin A (stefin A)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP7 dual specificity phosphatase 7
ENOPH1 enolase-phosphatase 1
EXOSC4 exosome component 4
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
GATA2 GATA binding protein 2
GATA3 GATA binding protein 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
HSPA1A heat shock 70kDa protein 1A
IL18 interleukin 18
JADE2 jade family PHD finger 2
JAG1 jagged 1
KLF4 Kruppel-like factor 4 (gut)
KRT14 keratin 14, type I
KRT6A keratin 6A, type II
LY6D lymphocyte antigen 6 complex, locus D
NOP16 NOP16 nucleolar protein
PHYH phytanoyl-CoA 2-hydroxylase
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPIF peptidylprolyl isomerase F
RXRA retinoid X receptor, alpha
SFN stratifin
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPRR1B small proline-rich protein 1B
STAR steroidogenic acute regulatory protein
TBX2 T-box 2
TOR1A torsin family 1, member A (torsin A)
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)