BRD-K77877933_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

226 genes differentially expressed following the BRD-K77877933_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ANKRD11 ankyrin repeat domain 11
ARF4 ADP-ribosylation factor 4
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BAG3 BCL2-associated athanogene 3
BHLHE40 basic helix-loop-helix family, member e40
BTG1 B-cell translocation gene 1, anti-proliferative
BTG3 BTG family, member 3
C1ORF27 chromosome 1 open reading frame 27
CCNL1 cyclin L1
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL1A1 collagen, type I, alpha 1
COL5A1 collagen, type V, alpha 1
COL6A3 collagen, type VI, alpha 3
CREB3L2 cAMP responsive element binding protein 3-like 2
CSRP2 cysteine and glycine-rich protein 2
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EIF1 eukaryotic translation initiation factor 1
ELANE elastase, neutrophil expressed
ELL2 elongation factor, RNA polymerase II, 2
FAM129A family with sequence similarity 129, member A
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FKBP11 FK506 binding protein 11, 19 kDa
FKBP14 FK506 binding protein 14, 22 kDa
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GCLM glutamate-cysteine ligase, modifier subunit
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GRB10 growth factor receptor-bound protein 10
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGHM immunoglobulin heavy constant mu
IGKV4-1 immunoglobulin kappa variable 4-1
IGLJ3 immunoglobulin lambda joining 3
IGLV3-19 immunoglobulin lambda variable 3-19
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM6A lysine (K)-specific demethylase 6A
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
LAPTM5 lysosomal protein transmembrane 5
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MBNL2 muscleblind-like splicing regulator 2
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR22HG MIR22 host gene
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUCB2 nucleobindin 2
ODC1 ornithine decarboxylase 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAUR plasminogen activator, urokinase receptor
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RABGGTB Rab geranylgeranyltransferase, beta subunit
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RLF rearranged L-myc fusion
RND3 Rho family GTPase 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SEC31A SEC31 homolog A (S. cerevisiae)
SERP1 stress-associated endoplasmic reticulum protein 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SIK1 salt-inducible kinase 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SMAD7 SMAD family member 7
SNAI2 snail family zinc finger 2
SRGN serglycin
STC2 stanniocalcin 2
TDO2 tryptophan 2,3-dioxygenase
TGFBI transforming growth factor, beta-induced, 68kDa
THBD thrombomodulin
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM39A transmembrane protein 39A
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIB1 tribbles pseudokinase 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UFM1 ubiquitin-fold modifier 1
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XIST X inactive specific transcript (non-protein coding)
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
ADD3 adducin 3 (gamma)
AK4 adenylate kinase 4
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
APLP2 amyloid beta (A4) precursor-like protein 2
APOD apolipoprotein D
ASCL1 achaete-scute family bHLH transcription factor 1
ASF1B anti-silencing function 1B histone chaperone
ASRGL1 asparaginase like 1
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
B3GNT1
BAD BCL2-associated agonist of cell death
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CBX1 chromobox homolog 1
CBX5 chromobox homolog 5
CCDC109B coiled-coil domain containing 109B
CCNA2 cyclin A2
CCNG1 cyclin G1
CDC25B cell division cycle 25B
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CHRDL1 chordin-like 1
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous)
CPNE3 copine III
CSK c-src tyrosine kinase
CTSC cathepsin C
CYFIP2 cytoplasmic FMR1 interacting protein 2
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHFR dihydrofolate reductase
EBP emopamil binding protein (sterol isomerase)
ELOVL6 ELOVL fatty acid elongase 6
ETFB electron-transfer-flavoprotein, beta polypeptide
FASN fatty acid synthase
FKBP1B FK506 binding protein 1B, 12.6 kDa
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GAS1 growth arrest-specific 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPX3 glutathione peroxidase 3
HADH hydroxyacyl-CoA dehydrogenase
ICMT isoprenylcysteine carboxyl methyltransferase
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KIAA0101 KIAA0101
LAGE3 L antigen family, member 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIG1 ligase I, DNA, ATP-dependent
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LY6E lymphocyte antigen 6 complex, locus E
LYPLA1 lysophospholipase I
MCM3 minichromosome maintenance complex component 3
MUC1 mucin 1, cell surface associated
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAAA N-acylethanolamine acid amidase
NFIB nuclear factor I/B
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NME4 NME/NM23 nucleoside diphosphate kinase 4
NMU neuromedin U
NR2F2 nuclear receptor subfamily 2, group F, member 2
NREP neuronal regeneration related protein
NUP210 nucleoporin 210kDa
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PNMAL1 paraneoplastic Ma antigen family-like 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROM1 prominin 1
RAD54B RAD54 homolog B (S. cerevisiae)
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RHOBTB3 Rho-related BTB domain containing 3
RPA1 replication protein A1, 70kDa
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
S100A13 S100 calcium binding protein A13
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPP1 selenoprotein P, plasma, 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
STMN1 stathmin 1
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TM7SF2 transmembrane 7 superfamily member 2
TMEM106C transmembrane protein 106C
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX3 TOX high mobility group box family member 3
TUBB tubulin, beta class I
TYMS thymidylate synthetase
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)