BRD-K77830450_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

49 genes differentially expressed following the BRD-K77830450_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AKR1C3 aldo-keto reductase family 1, member C3
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
BPHL biphenyl hydrolase-like (serine hydrolase)
BTG1 B-cell translocation gene 1, anti-proliferative
COL15A1 collagen, type XV, alpha 1
DDIT4 DNA-damage-inducible transcript 4
DLK1 delta-like 1 homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FTH1 ferritin, heavy polypeptide 1
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IGFBP5 insulin-like growth factor binding protein 5
IL17RB interleukin 17 receptor B
ITM2A integral membrane protein 2A
MAN1A1 mannosidase, alpha, class 1A, member 1
MMP12 matrix metallopeptidase 12
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SULF1 sulfatase 1
TBX3 T-box 3
TMEM2 transmembrane protein 2
TMEM30B transmembrane protein 30B
TNS1 tensin 1
TPBG trophoblast glycoprotein
TRIM2 tripartite motif containing 2

decreased expression

Symbol Name
CAPN2 calpain 2, (m/II) large subunit
CDC42 cell division cycle 42
HMGA2 high mobility group AT-hook 2
IGFBP1 insulin-like growth factor binding protein 1
JAG1 jagged 1
LRP4 low density lipoprotein receptor-related protein 4
NEFL neurofilament, light polypeptide
PDGFA platelet-derived growth factor alpha polypeptide
PLAC8 placenta-specific 8
PNMA2 paraneoplastic Ma antigen 2
PRMT1 protein arginine methyltransferase 1
PRSS23 protease, serine, 23
PTPN12 protein tyrosine phosphatase, non-receptor type 12
SCEL sciellin
SLPI secretory leukocyte peptidase inhibitor
TPM1 tropomyosin 1 (alpha)