BRD-K77547920_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

149 genes differentially expressed following the BRD-K77547920_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEMIP cell migration inducing protein, hyaluronan binding
CLU clusterin
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ELANE elastase, neutrophil expressed
EMP1 epithelial membrane protein 1
FOSL1 FOS-like antigen 1
GCLM glutamate-cysteine ligase, modifier subunit
HCAR3 hydroxycarboxylic acid receptor 3
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFRD1 interferon-related developmental regulator 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL1R2 interleukin 1 receptor, type II
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
LAMB3 laminin, beta 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MOK MOK protein kinase
MUC4 mucin 4, cell surface associated
MUC5B mucin 5B, oligomeric mucus/gel-forming
NAMPT nicotinamide phosphoribosyltransferase
NFIL3 nuclear factor, interleukin 3 regulated
ODC1 ornithine decarboxylase 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PER2 period circadian clock 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIR pirin (iron-binding nuclear protein)
PKP1 plakophilin 1
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
S100P S100 calcium binding protein P
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SERTAD2 SERTA domain containing 2
SFN stratifin
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SRGN serglycin
STC2 stanniocalcin 2
STK38L serine/threonine kinase 38 like
TBX3 T-box 3
TGFBI transforming growth factor, beta-induced, 68kDa
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TXNL4B thioredoxin-like 4B
TXNRD1 thioredoxin reductase 1
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ADCY1 adenylate cyclase 1 (brain)
ALDOB aldolase B, fructose-bisphosphate
ALOX15B arachidonate 15-lipoxygenase, type B
ATP5H ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d
B3GNT1
BASP1 brain abundant, membrane attached signal protein 1
C3 complement component 3
C7 complement component 7
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CCNF cyclin F
CCNG2 cyclin G2
CDK1 cyclin-dependent kinase 1
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CXCL14 chemokine (C-X-C motif) ligand 14
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DHCR24 24-dehydrocholesterol reductase
EFHD1 EF-hand domain family, member D1
ELOVL6 ELOVL fatty acid elongase 6
FABP4 fatty acid binding protein 4, adipocyte
FAM13A family with sequence similarity 13, member A
FASN fatty acid synthase
FSTL1 follistatin-like 1
FXYD2 FXYD domain containing ion transport regulator 2
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GJA1 gap junction protein, alpha 1, 43kDa
GPX3 glutathione peroxidase 3
GSPT2 G1 to S phase transition 2
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUSBP3 glucuronidase, beta pseudogene 3
HN1 hematological and neurological expressed 1
HOXA5 homeobox A5
INSIG1 insulin induced gene 1
KIAA0907 KIAA0907
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LRRC17 leucine rich repeat containing 17
MARCKSL1 MARCKS-like 1
MDK midkine (neurite growth-promoting factor 2)
MEIS1 Meis homeobox 1
MREG melanoregulin
MSMO1 methylsterol monooxygenase 1
NFIB nuclear factor I/B
NR2F6 nuclear receptor subfamily 2, group F, member 6
NREP neuronal regeneration related protein
NUP85 nucleoporin 85kDa
PEG10 paternally expressed 10
PLN phospholamban
PRR15L proline rich 15-like
PSRC1 proline/serine-rich coiled-coil 1
PTGIS prostaglandin I2 (prostacyclin) synthase
RBM3 RNA binding motif (RNP1, RRM) protein 3
RGS5 regulator of G-protein signaling 5
RTN2 reticulon 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFPI2 tissue factor pathway inhibitor 2
TMEM164 transmembrane protein 164
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X
VCAN versican