BRD-K77547920_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

296 genes differentially expressed following the BRD-K77547920_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
ACLY ATP citrate lyase
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANXA1 annexin A1
AQP3 aquaporin 3 (Gill blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BIN1 bridging integrator 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CAPN2 calpain 2, (m/II) large subunit
CBR3 carbonyl reductase 3
CCL5 chemokine (C-C motif) ligand 5
CD99 CD99 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CLCN3 chloride channel, voltage-sensitive 3
COL6A2 collagen, type VI, alpha 2
COMP cartilage oligomeric matrix protein
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTSL cathepsin L
CTSZ cathepsin Z
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DUSP3 dual specificity phosphatase 3
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FGFR3 fibroblast growth factor receptor 3
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FOXD1 forkhead box D1
FSCN1 fascin actin-bundling protein 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GLS glutaminase
GREM1 gremlin 1, DAN family BMP antagonist
GSTP1 glutathione S-transferase pi 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HAPLN1 hyaluronan and proteoglycan link protein 1
HMOX1 heme oxygenase 1
HOPX HOP homeobox
IDS iduronate 2-sulfatase
IFRD1 interferon-related developmental regulator 1
INHBA inhibin, beta A
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KIAA0368 KIAA0368
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAMA3 laminin, alpha 3
LARP6 La ribonucleoprotein domain family, member 6
LGALS8 lectin, galactoside-binding, soluble, 8
LRP10 low density lipoprotein receptor-related protein 10
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAP1B microtubule-associated protein 1B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NMRK1 nicotinamide riboside kinase 1
NPC1 Niemann-Pick disease, type C1
NQO2 NAD(P)H dehydrogenase, quinone 2
ODC1 ornithine decarboxylase 1
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM4 PDZ and LIM domain 4
PERP PERP, TP53 apoptosis effector
PGD phosphogluconate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PIR pirin (iron-binding nuclear protein)
PKP1 plakophilin 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
RALB v-ral simian leukemia viral oncogene homolog B
RAP1GAP RAP1 GTPase activating protein
RBMS1 RNA binding motif, single stranded interacting protein 1
RIOK3 RIO kinase 3
RIT1 Ras-like without CAAX 1
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERTAD2 SERTA domain containing 2
SFN stratifin
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR2B small proline-rich protein 2B
SPRR3 small proline-rich protein 3
SQSTM1 sequestosome 1
STX1A syntaxin 1A (brain)
TALDO1 transaldolase 1
TGFBI transforming growth factor, beta-induced, 68kDa
TMBIM1 transmembrane BAX inhibitor motif containing 1
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPM4 tropomyosin 4
TRIB1 tribbles pseudokinase 1
TRIM16 tripartite motif containing 16
TRIM29 tripartite motif containing 29
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TXN thioredoxin
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UPP1 uridine phosphorylase 1
ZFAND5 zinc finger, AN1-type domain 5
ZYX zyxin

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
AGR2 anterior gradient 2
ALB albumin
AMIGO2 adhesion molecule with Ig-like domain 2
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARL3 ADP-ribosylation factor-like 3
ARMT1 acidic residue methyltransferase 1
ASCL1 achaete-scute family bHLH transcription factor 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BCHE butyrylcholinesterase
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C3 complement component 3
C4BPA complement component 4 binding protein, alpha
C7 complement component 7
CCNA2 cyclin A2
CD200 CD200 molecule
CDC20 cell division cycle 20
CDC7 cell division cycle 7
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CENPA centromere protein A
CENPM centromere protein M
CHEK2 checkpoint kinase 2
CKS2 CDC28 protein kinase regulatory subunit 2
CTSH cathepsin H
CXCL12 chemokine (C-X-C motif) ligand 12
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DEPTOR DEP domain containing MTOR-interacting protein
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DLK1 delta-like 1 homolog (Drosophila)
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
ELOVL6 ELOVL fatty acid elongase 6
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
ESR1 estrogen receptor 1
FANCI Fanconi anemia, complementation group I
FBP1 fructose-1,6-bisphosphatase 1
FBXO5 F-box protein 5
FEN1 flap structure-specific endonuclease 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GFRA1 GDNF family receptor alpha 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GSTM3 glutathione S-transferase mu 3 (brain)
GTSE1 G-2 and S-phase expressed 1
HADH hydroxyacyl-CoA dehydrogenase
HELLS helicase, lymphoid-specific
HLF hepatic leukemia factor
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNMT histamine N-methyltransferase
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI16 interferon, gamma-inducible protein 16
IGF1 insulin-like growth factor 1 (somatomedin C)
IL17RB interleukin 17 receptor B
ISYNA1 inositol-3-phosphate synthase 1
JCHAIN joining chain of multimeric IgA and IgM
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT23 keratin 23, type I
LAGE3 L antigen family, member 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM2 minichromosome maintenance complex component 2
MEIS2 Meis homeobox 2
METTL7A methyltransferase like 7A
MT1E metallothionein 1E
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MUC16 mucin 16, cell surface associated
MXRA5 matrix-remodelling associated 5
MYB v-myb avian myeloblastosis viral oncogene homolog
NBN nibrin
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NET1 neuroepithelial cell transforming 1
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NT5DC2 5'-nucleotidase domain containing 2
NUSAP1 nucleolar and spindle associated protein 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PBK PDZ binding kinase
PBX1 pre-B-cell leukemia homeobox 1
PCNA proliferating cell nuclear antigen
PDGFC platelet derived growth factor C
PEG10 paternally expressed 10
PLAT plasminogen activator, tissue
PLK1 polo-like kinase 1
PLS1 plastin 1
PNMAL1 paraneoplastic Ma antigen family-like 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRSS23 protease, serine, 23
PTTG1 pituitary tumor-transforming 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RPA3 replication protein A3, 14kDa
RPIA ribose 5-phosphate isomerase A
RRM2 ribonucleotide reductase M2
SALL2 spalt-like transcription factor 2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPC25 SPC25, NDC80 kinetochore complex component
SPDEF SAM pointed domain containing ETS transcription factor
STMN1 stathmin 1
SUB1 SUB1 homolog (S. cerevisiae)
SYBU syntabulin (syntaxin-interacting)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
THYN1 thymocyte nuclear protein 1
TMEM106C transmembrane protein 106C
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRMT5 tRNA methyltransferase 5
TRPS1 trichorhinophalangeal syndrome I
TSPAN6 tetraspanin 6
TTK TTK protein kinase
TUBB tubulin, beta class I
TUSC3 tumor suppressor candidate 3
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
VRK1 vaccinia related kinase 1
WEE1 WEE1 G2 checkpoint kinase
WFDC2 WAP four-disulfide core domain 2
ZWINT ZW10 interacting kinetochore protein