BRD-K77547509_3-cyclohexyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

148 genes differentially expressed following the BRD-K77547509_3-cyclohexyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APLP2 amyloid beta (A4) precursor-like protein 2
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
CD99 CD99 molecule
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLU clusterin
CRIP1 cysteine-rich protein 1 (intestinal)
CSTA cystatin A (stefin A)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DSG3 desmoglein 3
DUSP14 dual specificity phosphatase 14
ELL2 elongation factor, RNA polymerase II, 2
EMP1 epithelial membrane protein 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
EZR ezrin
FASTKD5 FAST kinase domains 5
FBXO11 F-box protein 11
FGFR3 fibroblast growth factor receptor 3
FN1 fibronectin 1
FSCN1 fascin actin-bundling protein 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GLRX glutaredoxin (thioltransferase)
GSTP1 glutathione S-transferase pi 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IDI1 isopentenyl-diphosphate delta isomerase 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
INSIG1 insulin induced gene 1
IRX5 iroquois homeobox 5
ISCA1 iron-sulfur cluster assembly 1
JUP junction plakoglobin
KLHL7 kelch-like family member 7
KRT4 keratin 4, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LCN2 lipocalin 2
LMO2 LIM domain only 2 (rhombotin-like 1)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP2K3 mitogen-activated protein kinase kinase 3
MTSS1 metastasis suppressor 1
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NDRG1 N-myc downstream regulated 1
NPY neuropeptide Y
NR4A3 nuclear receptor subfamily 4, group A, member 3
PI3 peptidase inhibitor 3, skin-derived
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PRDX1 peroxiredoxin 1
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRSS8 protease, serine, 8
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
S100A10 S100 calcium binding protein A10
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SELENBP1 selenium binding protein 1
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SLPI secretory leukocyte peptidase inhibitor
SOX4 SRY (sex determining region Y)-box 4
TACSTD2 tumor-associated calcium signal transducer 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
TSC22D1 TSC22 domain family, member 1
TSPAN7 tetraspanin 7
TUBA1A tubulin, alpha 1a
VAT1 vesicle amine transport 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AREG amphiregulin
ARMCX2 armadillo repeat containing, X-linked 2
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
BHLHE41 basic helix-loop-helix family, member e41
C2CD5 C2 calcium-dependent domain containing 5
C3ORF14 chromosome 3 open reading frame 14
CAPRIN2 caprin family member 2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDK12 cyclin-dependent kinase 12
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
ETV5 ets variant 5
EXOC1 exocyst complex component 1
FAM13A family with sequence similarity 13, member A
FBN1 fibrillin 1
FHL2 four and a half LIM domains 2
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GOLGA8A golgin A8 family, member A
GPX2 glutathione peroxidase 2
GSAP gamma-secretase activating protein
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
INTS3 integrator complex subunit 3
JADE2 jade family PHD finger 2
LOC100505650 uncharacterized LOC100505650
MACF1 microtubule-actin crosslinking factor 1
MBNL2 muscleblind-like splicing regulator 2
MECOM MDS1 and EVI1 complex locus
MET MET proto-oncogene, receptor tyrosine kinase
MFAP5 microfibrillar associated protein 5
MTCL1 microtubule crosslinking factor 1
MTDH metadherin
MX1 MX dynamin-like GTPase 1
NFIB nuclear factor I/B
NID2 nidogen 2 (osteonidogen)
NMT1 N-myristoyltransferase 1
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OXR1 oxidation resistance 1
OXTR oxytocin receptor
PBX3 pre-B-cell leukemia homeobox 3
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLXDC1 plexin domain containing 1
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
PPARG peroxisome proliferator-activated receptor gamma
PTGIS prostaglandin I2 (prostacyclin) synthase
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic)
RBBP8 retinoblastoma binding protein 8
RECQL RecQ helicase-like
RNMT RNA (guanine-7-) methyltransferase
RPS4Y1 ribosomal protein S4, Y-linked 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEH1L SEH1-like (S. cerevisiae)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SLC38A2 solute carrier family 38, member 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPG11 spastic paraplegia 11 (autosomal recessive)
SPINK1 serine peptidase inhibitor, Kazal type 1
STAMBP STAM binding protein
STAR steroidogenic acute regulatory protein
TCERG1 transcription elongation regulator 1
TFPI2 tissue factor pathway inhibitor 2
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM2 transmembrane protein 2
TMEM5 transmembrane protein 5
TRIP6 thyroid hormone receptor interactor 6
TRPS1 trichorhinophalangeal syndrome I
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN8 tetraspanin 8
UBE3C ubiquitin protein ligase E3C
USO1 USO1 vesicle transport factor
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF131 zinc finger protein 131
ZNF160 zinc finger protein 160