BRD-K77480336_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

146 genes differentially expressed following the BRD-K77480336_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ALB albumin
AMIGO2 adhesion molecule with Ig-like domain 2
ARG2 arginase 2
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ATF3 activating transcription factor 3
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
BLNK B-cell linker
BTG2 BTG family, member 2
BTG3 BTG family, member 3
CAST calpastatin
CAV2 caveolin 2
CD40 CD40 molecule, TNF receptor superfamily member 5
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CKB creatine kinase, brain
CORO1A coronin, actin binding protein, 1A
CTH cystathionine gamma-lyase
CYR61 cysteine-rich, angiogenic inducer, 61
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
DUSP4 dual specificity phosphatase 4
FADS3 fatty acid desaturase 3
FAS Fas cell surface death receptor
FDXR ferredoxin reductase
FOSL1 FOS-like antigen 1
FSCN1 fascin actin-bundling protein 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
H2AFV H2A histone family, member V
HBEGF heparin-binding EGF-like growth factor
HOXB2 homeobox B2
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IDS iduronate 2-sulfatase
IER5 immediate early response 5
IL10RA interleukin 10 receptor, alpha
JAG1 jagged 1
L1CAM L1 cell adhesion molecule
LOC100505650 uncharacterized LOC100505650
LTB lymphotoxin beta (TNF superfamily, member 3)
MARCH2 membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
MKNK2 MAP kinase interacting serine/threonine kinase 2
MME membrane metallo-endopeptidase
MOSPD1 motile sperm domain containing 1
NID1 nidogen 1
NOTCH1 notch 1
OLFM4 olfactomedin 4
PBX3 pre-B-cell leukemia homeobox 3
PDGFA platelet-derived growth factor alpha polypeptide
PELI1 pellino E3 ubiquitin protein ligase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RND3 Rho family GTPase 3
RNF11 ring finger protein 11
RTN2 reticulon 2
SERINC1 serine incorporator 1
SESN1 sestrin 1
SST somatostatin
STK17A serine/threonine kinase 17a
SYNGR3 synaptogyrin 3
TFPI2 tissue factor pathway inhibitor 2
TMBIM6 transmembrane BAX inhibitor motif containing 6
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM30A transmembrane protein 30A
TMEM47 transmembrane protein 47
TOB1 transducer of ERBB2, 1
TSC22D2 TSC22 domain family, member 2
TUBB2A tubulin, beta 2A class IIa
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
WDR26 WD repeat domain 26
ZBTB18 zinc finger and BTB domain containing 18
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
AGR2 anterior gradient 2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMD1 adenosylmethionine decarboxylase 1
APOD apolipoprotein D
AUTS2 autism susceptibility candidate 2
C1QA complement component 1, q subcomponent, A chain
CA12 carbonic anhydrase XII
CHI3L2 chitinase 3-like 2
CHSY1 chondroitin sulfate synthase 1
CYB5A cytochrome b5 type A (microsomal)
EAF2 ELL associated factor 2
EDNRA endothelin receptor type A
EVL Enah/Vasp-like
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
FNDC3B fibronectin type III domain containing 3B
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPNMB glycoprotein (transmembrane) nmb
GRWD1 glutamate-rich WD repeat containing 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HK2 hexokinase 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JARID2 jumonji, AT rich interactive domain 2
KAZN kazrin, periplakin interacting protein
KRT19 keratin 19, type I
LAMP5 lysosomal-associated membrane protein family, member 5
LTF lactotransferrin
LYZ lysozyme
MAP7 microtubule-associated protein 7
MBP myelin basic protein
MFAP5 microfibrillar associated protein 5
MLPH melanophilin
MMP9 matrix metallopeptidase 9
MRPS12 mitochondrial ribosomal protein S12
MTUS1 microtubule associated tumor suppressor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEBL nebulette
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NOP16 NOP16 nucleolar protein
OLFML2B olfactomedin-like 2B
PCOLCE2 procollagen C-endopeptidase enhancer 2
PMM2 phosphomannomutase 2
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PRKCD protein kinase C, delta
RHOBTB3 Rho-related BTB domain containing 3
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100B S100 calcium binding protein B
SATB1 SATB homeobox 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
TACSTD2 tumor-associated calcium signal transducer 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TNC tenascin C
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSKU tsukushi, small leucine rich proteoglycan
TUG1 taurine up-regulated 1 (non-protein coding)
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
WDR3 WD repeat domain 3
WWC1 WW and C2 domain containing 1