BRD-K77480336_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

94 genes differentially expressed following the BRD-K77480336_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AREG amphiregulin
BASP1 brain abundant, membrane attached signal protein 1
BHLHE41 basic helix-loop-helix family, member e41
CCDC92 coiled-coil domain containing 92
CCND2 cyclin D2
CD52 CD52 molecule
CDC42 cell division cycle 42
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHIC2 cysteine-rich hydrophobic domain 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CRABP1 cellular retinoic acid binding protein 1
CTSB cathepsin B
CTSK cathepsin K
CXCL12 chemokine (C-X-C motif) ligand 12
DDB2 damage-specific DNA binding protein 2, 48kDa
EIF5A eukaryotic translation initiation factor 5A
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ERLIN2 ER lipid raft associated 2
FAS Fas cell surface death receptor
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDXR ferredoxin reductase
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GLTP glycolipid transfer protein
GREM1 gremlin 1, DAN family BMP antagonist
ICAM1 intercellular adhesion molecule 1
INPP1 inositol polyphosphate-1-phosphatase
JUN jun proto-oncogene
KIAA0753 KIAA0753
KRT14 keratin 14, type I
LAMP1 lysosomal-associated membrane protein 1
LDLR low density lipoprotein receptor
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MICALL1 MICAL-like 1
MSMO1 methylsterol monooxygenase 1
MT1X metallothionein 1X
NEU1 sialidase 1 (lysosomal sialidase)
NINJ1 ninjurin 1
NPC2 Niemann-Pick disease, type C2
NRIP1 nuclear receptor interacting protein 1
PEG3 paternally expressed 3
PHF1 PHD finger protein 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLSCR3 phospholipid scramblase 3
RAB11FIP1 RAB11 family interacting protein 1 (class I)
SATB1 SATB homeobox 1
SCPEP1 serine carboxypeptidase 1
SESN1 sestrin 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SQSTM1 sequestosome 1
TIGAR TP53 induced glycolysis regulatory phosphatase
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOB1 transducer of ERBB2, 1
TP63 tumor protein p63
VCAN versican
ZMAT3 zinc finger, matrin-type 3
ZNF185 zinc finger protein 185 (LIM domain)

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
BZW2 basic leucine zipper and W2 domains 2
CCND1 cyclin D1
CD47 CD47 molecule
CFB complement factor B
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
FABP7 fatty acid binding protein 7, brain
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GRIA2 glutamate receptor, ionotropic, AMPA 2
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
KIF20A kinesin family member 20A
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MTSS1 metastasis suppressor 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PRAME preferentially expressed antigen in melanoma
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PWP1 PWP1 homolog (S. cerevisiae)
REEP1 receptor accessory protein 1
RTN1 reticulon 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
TGFBI transforming growth factor, beta-induced, 68kDa
TSPAN7 tetraspanin 7