BRD-K77014406_4-Isopropoxy-2-(3-methoxy-phenyl)-quinazoline BRD-K77014406_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

109 genes differentially expressed following the BRD-K77014406_4-Isopropoxy-2-(3-methoxy-phenyl)-quinazoline BRD-K77014406_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADGRF5 adhesion G protein-coupled receptor F5
ADM adrenomedullin
ALOX5 arachidonate 5-lipoxygenase
ANXA4 annexin A4
ARL4C ADP-ribosylation factor-like 4C
ARMCX1 armadillo repeat containing, X-linked 1
ATF3 activating transcription factor 3
BTG2 BTG family, member 2
C6ORF62 chromosome 6 open reading frame 62
CADM1 cell adhesion molecule 1
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2
CAST calpastatin
CD52 CD52 molecule
CD9 CD9 molecule
CD93 CD93 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC2B C-type lectin domain family 2, member B
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CTGF connective tissue growth factor
CXCL14 chemokine (C-X-C motif) ligand 14
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DENND1B DENN/MADD domain containing 1B
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EDN1 endothelin 1
EIF5 eukaryotic translation initiation factor 5
EPAS1 endothelial PAS domain protein 1
FHL1 four and a half LIM domains 1
FLT1 fms-related tyrosine kinase 1
FRZB frizzled-related protein
FZD1 frizzled class receptor 1
GAL galanin/GMAP prepropeptide
GPNMB glycoprotein (transmembrane) nmb
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HBB hemoglobin, beta
HCAR3 hydroxycarboxylic acid receptor 3
HIST1H2BD histone cluster 1, H2bd
IDO1 indoleamine 2,3-dioxygenase 1
IGHM immunoglobulin heavy constant mu
KDR kinase insert domain receptor
LMO3 LIM domain only 3 (rhombotin-like 2)
LPAR6 lysophosphatidic acid receptor 6
MPZL2 myelin protein zero-like 2
NOTCH1 notch 1
NPTX2 neuronal pentraxin II
PCLO piccolo presynaptic cytomatrix protein
PDZD2 PDZ domain containing 2
PLAU plasminogen activator, urokinase
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGCC regulator of cell cycle
RND3 Rho family GTPase 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RSAD2 radical S-adenosyl methionine domain containing 2
SFRP4 secreted frizzled-related protein 4
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SNAI2 snail family zinc finger 2
SNX7 sorting nexin 7
SPON2 spondin 2, extracellular matrix protein
TCF4 transcription factor 4
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TYROBP TYRO protein tyrosine kinase binding protein
VEGFA vascular endothelial growth factor A
VWF von Willebrand factor

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ATXN1 ataxin 1
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCL19 chemokine (C-C motif) ligand 19
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CLU clusterin
COL9A3 collagen, type IX, alpha 3
CTSH cathepsin H
CYBA cytochrome b-245, alpha polypeptide
CYFIP2 cytoplasmic FMR1 interacting protein 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
EXOSC4 exosome component 4
GMDS GDP-mannose 4,6-dehydratase
GPRC5A G protein-coupled receptor, class C, group 5, member A
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
LOC100505650 uncharacterized LOC100505650
LTBP3 latent transforming growth factor beta binding protein 3
LTF lactotransferrin
MAMLD1 mastermind-like domain containing 1
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MSRB2 methionine sulfoxide reductase B2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCOA4 nuclear receptor coactivator 4
NUP210 nucleoporin 210kDa
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
PSAT1 phosphoserine aminotransferase 1
SELL selectin L
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRSF9 serine/arginine-rich splicing factor 9
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TLR4 toll-like receptor 4
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TSPAN8 tetraspanin 8