BRD-K76938712_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

183 genes differentially expressed following the BRD-K76938712_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADGRE5 adhesion G protein-coupled receptor E5
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGR2 anterior gradient 2
AIM1 absent in melanoma 1
ALDOC aldolase C, fructose-bisphosphate
AREG amphiregulin
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASPH aspartate beta-hydroxylase
C3 complement component 3
CALR calreticulin
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPG capping protein (actin filament), gelsolin-like
CCNG2 cyclin G2
CD14 CD14 molecule
CD163 CD163 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CES1 carboxylesterase 1
CFD complement factor D (adipsin)
COL1A1 collagen, type I, alpha 1
CP ceruloplasmin (ferroxidase)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CTSL cathepsin L
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
DHRS7 dehydrogenase/reductase (SDR family) member 7
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPYSL3 dihydropyrimidinase-like 3
DUOX2 dual oxidase 2
ECM1 extracellular matrix protein 1
EDNRA endothelin receptor type A
ENAH enabled homolog (Drosophila)
ENO2 enolase 2 (gamma, neuronal)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPS8 epidermal growth factor receptor pathway substrate 8
FABP1 fatty acid binding protein 1, liver
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FBLN1 fibulin 1
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FN1 fibronectin 1
FOXO4 forkhead box O4
FXYD5 FXYD domain containing ion transport regulator 5
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GPX2 glutathione peroxidase 2
GSE1 Gse1 coiled-coil protein
GSTA4 glutathione S-transferase alpha 4
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER3 immediate early response 3
IER5 immediate early response 5
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP6 insulin-like growth factor binding protein 6
IGSF3 immunoglobulin superfamily, member 3
IL32 interleukin 32
IL7R interleukin 7 receptor
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KRT18 keratin 18, type I
KYNU kynureninase
L1CAM L1 cell adhesion molecule
LAMB1 laminin, beta 1
LDLR low density lipoprotein receptor
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGALS4 lectin, galactoside-binding, soluble, 4
LIMCH1 LIM and calponin homology domains 1
LIPA lipase A, lysosomal acid, cholesterol esterase
MAOA monoamine oxidase A
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMD monocyte to macrophage differentiation-associated
MYH11 myosin, heavy chain 11, smooth muscle
NDRG1 N-myc downstream regulated 1
NPTX2 neuronal pentraxin II
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
PCCA propionyl CoA carboxylase, alpha polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PFKM phosphofructokinase, muscle
PGM1 phosphoglucomutase 1
PHGDH phosphoglycerate dehydrogenase
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLAU plasminogen activator, urokinase
PLIN2 perilipin 2
PLS1 plastin 1
PPAP2C phosphatidic acid phosphatase type 2C
PRAME preferentially expressed antigen in melanoma
PROCR protein C receptor, endothelial
PRSS8 protease, serine, 8
RAB26 RAB26, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS10 regulator of G-protein signaling 10
RGS16 regulator of G-protein signaling 16
RHOBTB3 Rho-related BTB domain containing 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100A14 S100 calcium binding protein A14
S100A4 S100 calcium binding protein A4
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SDCBP syndecan binding protein (syntenin)
SELENBP1 selenium binding protein 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC22A18 solute carrier family 22, member 18
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SOX4 SRY (sex determining region Y)-box 4
STC1 stanniocalcin 1
STMN2 stathmin 2
STXBP1 syntaxin binding protein 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SYNGR3 synaptogyrin 3
SYT1 synaptotagmin I
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGM2 transglutaminase 2
TIMP1 TIMP metallopeptidase inhibitor 1
TMEM45A transmembrane protein 45A
TPSAB1 tryptase alpha/beta 1
TRIM2 tripartite motif containing 2
TSC22D1 TSC22 domain family, member 1
TSKU tsukushi, small leucine rich proteoglycan
TXNRD1 thioredoxin reductase 1
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAN versican
VIM vimentin
WNT5A wingless-type MMTV integration site family, member 5A
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
APP amyloid beta (A4) precursor protein
BIRC5 baculoviral IAP repeat containing 5
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CDC25A cell division cycle 25A
DBF4 DBF4 zinc finger
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUT deoxyuridine triphosphatase
EIF5 eukaryotic translation initiation factor 5
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
FEN1 flap structure-specific endonuclease 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GRWD1 glutamate-rich WD repeat containing 1
HIST1H4C histone cluster 1, H4c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ICAM3 intercellular adhesion molecule 3
KRT14 keratin 14, type I
LIG1 ligase I, DNA, ATP-dependent
LMO4 LIM domain only 4
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MCM4 minichromosome maintenance complex component 4
MRPS12 mitochondrial ribosomal protein S12
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa
PCNA proliferating cell nuclear antigen
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPIF peptidylprolyl isomerase F
RFC5 replication factor C (activator 1) 5, 36.5kDa
SPRR1A small proline-rich protein 1A
SRM spermidine synthase
TCF4 transcription factor 4
TRAPPC2L trafficking protein particle complex 2-like
ZNF432 zinc finger protein 432