BRD-K76907295_VU0418947-2_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

302 genes differentially expressed following the BRD-K76907295_VU0418947-2_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ADM adrenomedullin
ALDOA aldolase A, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ANKRD10 ankyrin repeat domain 10
AQP8 aquaporin 8
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BACE2 beta-site APP-cleaving enzyme 2
BAMBI BMP and activin membrane-bound inhibitor
BGN biglycan
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BTG1 B-cell translocation gene 1, anti-proliferative
CA4 carbonic anhydrase IV
CADM1 cell adhesion molecule 1
CARS cysteinyl-tRNA synthetase
CCND1 cyclin D1
CCP110 centriolar coiled coil protein 110kDa
CD177 CD177 molecule
CD24 CD24 molecule
CD300A CD300a molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK19 cyclin-dependent kinase 19
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CES1 carboxylesterase 1
CHMP1B charged multivesicular body protein 1B
COL11A1 collagen, type XI, alpha 1
COMP cartilage oligomeric matrix protein
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CRYAB crystallin, alpha B
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND5A DENN/MADD domain containing 5A
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DOK4 docking protein 4
DPYSL4 dihydropyrimidinase-like 4
DSC2 desmocollin 2
DSP desmoplakin
EGFR epidermal growth factor receptor
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ENO2 enolase 2 (gamma, neuronal)
EPRS glutamyl-prolyl-tRNA synthetase
FAM129A family with sequence similarity 129, member A
FAM134B family with sequence similarity 134, member B
FAM162A family with sequence similarity 162, member A
FHL1 four and a half LIM domains 1
FOSL2 FOS-like antigen 2
FOXO4 forkhead box O4
FRY furry homolog (Drosophila)
FTH1 ferritin, heavy polypeptide 1
GAB2 GRB2-associated binding protein 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45B growth arrest and DNA-damage-inducible, beta
GAS7 growth arrest-specific 7
GBE1 glucan (1,4-alpha-), branching enzyme 1
GLUL glutamate-ammonia ligase
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GPRC5A G protein-coupled receptor, class C, group 5, member A
HEPH hephaestin
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HK2 hexokinase 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
INHBA inhibin, beta A
IRS2 insulin receptor substrate 2
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JCHAIN joining chain of multimeric IgA and IgM
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
KLHL24 kelch-like family member 24
KRT14 keratin 14, type I
KRT17 keratin 17, type I
LARP6 La ribonucleoprotein domain family, member 6
LIMCH1 LIM and calponin homology domains 1
LRP4 low density lipoprotein receptor-related protein 4
LSR lipolysis stimulated lipoprotein receptor
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALT1 MALT1 paracaspase
MAP1B microtubule-associated protein 1B
MAPT microtubule-associated protein tau
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MFAP5 microfibrillar associated protein 5
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MMP7 matrix metallopeptidase 7
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MXI1 MAX interactor 1, dimerization protein
MYO15B myosin XVB
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NRN1 neuritin 1
NUPR1 nuclear protein, transcriptional regulator, 1
OLFML2A olfactomedin-like 2A
OXSR1 oxidative stress responsive 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PALLD palladin, cytoskeletal associated protein
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKP phosphofructokinase, platelet
PGAM1 phosphoglycerate mutase 1 (brain)
PGK1 phosphoglycerate kinase 1
PHGDH phosphoglycerate dehydrogenase
PLCE1 phospholipase C, epsilon 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POSTN periostin, osteoblast specific factor
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTPRR protein tyrosine phosphatase, receptor type, R
RAB20 RAB20, member RAS oncogene family
RAB32 RAB32, member RAS oncogene family
RAP1GAP2 RAP1 GTPase activating protein 2
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS1 regulator of G-protein signaling 1
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
RPL38 ribosomal protein L38
RUNX3 runt-related transcription factor 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A2 secretoglobin, family 2A, member 2
SERTAD2 SERTA domain containing 2
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX4 SRY (sex determining region Y)-box 4
SPAG4 sperm associated antigen 4
SST somatostatin
STC2 stanniocalcin 2
TBX3 T-box 3
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFF3 trefoil factor 3 (intestinal)
TIMP3 TIMP metallopeptidase inhibitor 3
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM100 transmembrane protein 100
TMEM47 transmembrane protein 47
TMPRSS3 transmembrane protease, serine 3
TNIP1 TNFAIP3 interacting protein 1
TSC22D1 TSC22 domain family, member 1
TUBB2B tubulin, beta 2B class IIb
TXNRD1 thioredoxin reductase 1
VAT1 vesicle amine transport 1
VEGFA vascular endothelial growth factor A
WSB1 WD repeat and SOCS box containing 1
ZMYM2 zinc finger, MYM-type 2

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ACP6 acid phosphatase 6, lysophosphatidic
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
APRT adenine phosphoribosyltransferase
AQP3 aquaporin 3 (Gill blood group)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATP5I ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
C1QBP complement component 1, q subcomponent binding protein
CCDC109B coiled-coil domain containing 109B
CCDC85B coiled-coil domain containing 85B
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CD320 CD320 molecule
CD47 CD47 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CKS2 CDC28 protein kinase regulatory subunit 2
COA3 cytochrome c oxidase assembly factor 3
CTPS1 CTP synthase 1
CTSO cathepsin O
DCXR dicarbonyl/L-xylulose reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPAGT1 dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
DPYD dihydropyrimidine dehydrogenase
EIF5A eukaryotic translation initiation factor 5A
ELOVL6 ELOVL fatty acid elongase 6
ESRP2 epithelial splicing regulatory protein 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM3C family with sequence similarity 3, member C
FASN fatty acid synthase
FASTKD3 FAST kinase domains 3
FBP1 fructose-1,6-bisphosphatase 1
FJX1 four jointed box 1 (Drosophila)
FKBP5 FK506 binding protein 5
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
GATA3 GATA binding protein 3
GLDC glycine dehydrogenase (decarboxylating)
GRWD1 glutamate-rich WD repeat containing 1
HJURP Holliday junction recognition protein
HMG20B high mobility group 20B
HOMER2 homer scaffolding protein 2
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10
HSPA8 heat shock 70kDa protein 8
ICMT isoprenylcysteine carboxyl methyltransferase
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFI16 interferon, gamma-inducible protein 16
KAZN kazrin, periplakin interacting protein
KCTD12 potassium channel tetramerization domain containing 12
KIAA0100 KIAA0100
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LBR lamin B receptor
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAOA monoamine oxidase A
MELK maternal embryonic leucine zipper kinase
MRPL12 mitochondrial ribosomal protein L12
MRPL20 mitochondrial ribosomal protein L20
MRPL3 mitochondrial ribosomal protein L3
MRPS12 mitochondrial ribosomal protein S12
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCAPH non-SMC condensin I complex, subunit H
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NIT2 nitrilase family, member 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP56 NOP56 ribonucleoprotein
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUTF2 nuclear transport factor 2
PARP1 poly (ADP-ribose) polymerase 1
PCCB propionyl CoA carboxylase, beta polypeptide
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
POLD2 polymerase (DNA directed), delta 2, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPA2 pyrophosphatase (inorganic) 2
PRC1 protein regulator of cytokinesis 1
PRMT1 protein arginine methyltransferase 1
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
PTTG1 pituitary tumor-transforming 1
RAP1GAP RAP1 GTPase activating protein
RER1 retention in endoplasmic reticulum sorting receptor 1
RRM2 ribonucleotide reductase M2
RUVBL1 RuvB-like AAA ATPase 1
S100A8 S100 calcium binding protein A8
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SIGMAR1 sigma non-opioid intracellular receptor 1
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SMC4 structural maintenance of chromosomes 4
SRM spermidine synthase
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STOML2 stomatin (EPB72)-like 2
SYNGR2 synaptogyrin 2
TACC3 transforming, acidic coiled-coil containing protein 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TDO2 tryptophan 2,3-dioxygenase
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TK1 thymidine kinase 1, soluble
TMEM147 transmembrane protein 147
TMPO thymopoietin
TMX1 thioredoxin-related transmembrane protein 1
TMX4 thioredoxin-related transmembrane protein 4
TNC tenascin C
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TUSC3 tumor suppressor candidate 3
UBE2C ubiquitin-conjugating enzyme E2C
UBE2M ubiquitin-conjugating enzyme E2M
UBE2S ubiquitin-conjugating enzyme E2S
UMPS uridine monophosphate synthetase
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X
ZMPSTE24 zinc metallopeptidase STE24
ZWINT ZW10 interacting kinetochore protein