BRD-K76840893_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

99 genes differentially expressed following the BRD-K76840893_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACLY ATP citrate lyase
ACSL1 acyl-CoA synthetase long-chain family member 1
AKAP8L A kinase (PRKA) anchor protein 8-like
ALCAM activated leukocyte cell adhesion molecule
ANK2 ankyrin 2, neuronal
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
AXIN1 axin 1
BHLHE40 basic helix-loop-helix family, member e40
CCNG2 cyclin G2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC4 chloride intracellular channel 4
COL14A1 collagen, type XIV, alpha 1
CTH cystathionine gamma-lyase
DCLK1 doublecortin-like kinase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM129A family with sequence similarity 129, member A
FOXO3 forkhead box O3
G0S2 G0/G1 switch 2
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IER3 immediate early response 3
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
LAMP5 lysosomal-associated membrane protein family, member 5
LDLR low density lipoprotein receptor
LRRC16A leucine rich repeat containing 16A
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MSMO1 methylsterol monooxygenase 1
NFIB nuclear factor I/B
NPY1R neuropeptide Y receptor Y1
NTS neurotensin
OSBPL10 oxysterol binding protein-like 10
OSBPL8 oxysterol binding protein-like 8
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDLIM5 PDZ and LIM domain 5
PELI1 pellino E3 ubiquitin protein ligase 1
PSAP prosaposin
PSAT1 phosphoserine aminotransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SFRP1 secreted frizzled-related protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SIK3 SIK family kinase 3
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC38A2 solute carrier family 38, member 2
STC2 stanniocalcin 2
TAC1 tachykinin, precursor 1
TGIF1 TGFB-induced factor homeobox 1
TIMP1 TIMP metallopeptidase inhibitor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ALOX5AP arachidonate 5-lipoxygenase-activating protein
BAG3 BCL2-associated athanogene 3
CA2 carbonic anhydrase II
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL6A3 collagen, type VI, alpha 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FAIM Fas apoptotic inhibitory molecule
FAM107A family with sequence similarity 107, member A
FCGBP Fc fragment of IgG binding protein
GBP1 guanylate binding protein 1, interferon-inducible
GJA1 gap junction protein, alpha 1, 43kDa
H2AFX H2A histone family, member X
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
KCTD12 potassium channel tetramerization domain containing 12
KDM5D lysine (K)-specific demethylase 5D
LOX lysyl oxidase
LTBP1 latent transforming growth factor beta binding protein 1
PAEP progestagen-associated endometrial protein
PDLIM1 PDZ and LIM domain 1
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RGCC regulator of cell cycle
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SRSF7 serine/arginine-rich splicing factor 7
TCFL5 transcription factor-like 5 (basic helix-loop-helix)