BRD-K76840893_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

225 genes differentially expressed following the BRD-K76840893_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANKRD10 ankyrin repeat domain 10
APOD apolipoprotein D
APOLD1 apolipoprotein L domain containing 1
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL4C ADP-ribosylation factor-like 4C
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATF6 activating transcription factor 6
BGN biglycan
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNL1 cyclin L1
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
COL15A1 collagen, type XV, alpha 1
COL1A1 collagen, type I, alpha 1
COMP cartilage oligomeric matrix protein
CPD carboxypeptidase D
CREB3L2 cAMP responsive element binding protein 3-like 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTGF connective tissue growth factor
CTSK cathepsin K
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
DCLK1 doublecortin-like kinase 1
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDR1 discoidin domain receptor tyrosine kinase 1
DHCR24 24-dehydrocholesterol reductase
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DOCK9 dedicator of cytokinesis 9
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EIF1 eukaryotic translation initiation factor 1
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EVI2A ecotropic viral integration site 2A
FBLN1 fibulin 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FKBP11 FK506 binding protein 11, 19 kDa
FNDC3A fibronectin type III domain containing 3A
FNDC3B fibronectin type III domain containing 3B
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FTH1 ferritin, heavy polypeptide 1
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GPNMB glycoprotein (transmembrane) nmb
GULP1 GULP, engulfment adaptor PTB domain containing 1
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HYOU1 hypoxia up-regulated 1
IER3 immediate early response 3
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
IL7R interleukin 7 receptor
INHBA inhibin, beta A
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KDM3A lysine (K)-specific demethylase 3A
KLF6 Kruppel-like factor 6
KRT14 keratin 14, type I
KRT23 keratin 23, type I
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOTCH3 notch 3
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUCB2 nucleobindin 2
OSBPL10 oxysterol binding protein-like 10
PDE4B phosphodiesterase 4B, cAMP-specific
PEG10 paternally expressed 10
PERP PERP, TP53 apoptosis effector
PLVAP plasmalemma vesicle associated protein
PNRC1 proline-rich nuclear receptor coactivator 1
PPOX protoporphyrinogen oxidase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTN pleiotrophin
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RAP1GAP RAP1 GTPase activating protein
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RRAGD Ras-related GTP binding D
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERINC5 serine incorporator 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP4 secreted frizzled-related protein 4
SGK1 serum/glucocorticoid regulated kinase 1
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC16A6 solute carrier family 16, member 6
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC38A2 solute carrier family 38, member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SQSTM1 sequestosome 1
SST somatostatin
THBS2 thrombospondin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPBG trophoblast glycoprotein
TRIM2 tripartite motif containing 2
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
VAT1 vesicle amine transport 1
VEGFA vascular endothelial growth factor A
WIPI1 WD repeat domain, phosphoinositide interacting 1
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2
ZMYND8 zinc finger, MYND-type containing 8
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACOT7 acyl-CoA thioesterase 7
ATF5 activating transcription factor 5
BCHE butyrylcholinesterase
BIRC5 baculoviral IAP repeat containing 5
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCNF cyclin F
CD151 CD151 molecule (Raph blood group)
CD81 CD81 molecule
CDC25A cell division cycle 25A
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CEP55 centrosomal protein 55kDa
CLIC3 chloride intracellular channel 3
CLU clusterin
CRYZ crystallin, zeta (quinone reductase)
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL13 chemokine (C-X-C motif) ligand 13
DCK deoxycytidine kinase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EXOSC4 exosome component 4
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GSTM3 glutathione S-transferase mu 3 (brain)
HAT1 histone acetyltransferase 1
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
LIG1 ligase I, DNA, ATP-dependent
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM2 minichromosome maintenance complex component 2
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MRPL12 mitochondrial ribosomal protein L12
MRPL20 mitochondrial ribosomal protein L20
MSH6 mutS homolog 6
MSRB1 methionine sulfoxide reductase B1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NME4 NME/NM23 nucleoside diphosphate kinase 4
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
NUTF2 nuclear transport factor 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PCP4 Purkinje cell protein 4
PGAM1 phosphoglycerate mutase 1 (brain)
PLAC8 placenta-specific 8
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPIF peptidylprolyl isomerase F
PRC1 protein regulator of cytokinesis 1
PRPF4 pre-mRNA processing factor 4
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM1 ribonucleotide reductase M1
SEPW1 selenoprotein W, 1
SMC2 structural maintenance of chromosomes 2
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
STMN1 stathmin 1
TACC3 transforming, acidic coiled-coil containing protein 3
TFAM transcription factor A, mitochondrial
TMEM14A transmembrane protein 14A
TMPO thymopoietin
TPM1 tropomyosin 1 (alpha)
TRAPPC3 trafficking protein particle complex 3
TRIP13 thyroid hormone receptor interactor 13
TSPAN4 tetraspanin 4
TSPYL5 TSPY-like 5
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UNG uracil-DNA glycosylase
VRK1 vaccinia related kinase 1
ZWINT ZW10 interacting kinetochore protein