BRD-K76840893_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

103 genes differentially expressed following the BRD-K76840893_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APOD apolipoprotein D
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BACE2 beta-site APP-cleaving enzyme 2
BASP1 brain abundant, membrane attached signal protein 1
BHLHE41 basic helix-loop-helix family, member e41
BTG1 B-cell translocation gene 1, anti-proliferative
CAST calpastatin
CBS cystathionine-beta-synthase
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCNG2 cyclin G2
CDK14 cyclin-dependent kinase 14
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
EIF4B eukaryotic translation initiation factor 4B
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOLR1 folate receptor 1 (adult)
FOXO3 forkhead box O3
FST follistatin
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
JUNB jun B proto-oncogene
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCOLN1 mucolipin 1
MSMO1 methylsterol monooxygenase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MXI1 MAX interactor 1, dimerization protein
MYO10 myosin X
NFIL3 nuclear factor, interleukin 3 regulated
NUPR1 nuclear protein, transcriptional regulator, 1
RB1CC1 RB1-inducible coiled-coil 1
SARS seryl-tRNA synthetase
SASH1 SAM and SH3 domain containing 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SNAI2 snail family zinc finger 2
SPRED2 sprouty-related, EVH1 domain containing 2
SQSTM1 sequestosome 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TRIB3 tribbles pseudokinase 3
WASL Wiskott-Aldrich syndrome-like
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZMIZ1 zinc finger, MIZ-type containing 1
ZMYM2 zinc finger, MYM-type 2

decreased expression

Symbol Name
ALOX5AP arachidonate 5-lipoxygenase-activating protein
CA2 carbonic anhydrase II
CCND1 cyclin D1
CD14 CD14 molecule
CD24 CD24 molecule
CDC20 cell division cycle 20
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHMP4A charged multivesicular body protein 4A
CKB creatine kinase, brain
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTGF connective tissue growth factor
CYBB cytochrome b-245, beta polypeptide
DCN decorin
DDAH1 dimethylarginine dimethylaminohydrolase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DLK1 delta-like 1 homolog (Drosophila)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
HBB hemoglobin, beta
HMGB3 high mobility group box 3
HOXB7 homeobox B7
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
ITGA6 integrin, alpha 6
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KRT19 keratin 19, type I
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAT2A methionine adenosyltransferase II, alpha
MFAP3L microfibrillar-associated protein 3-like
MYCBP MYC binding protein
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRDX2 peroxiredoxin 2
PXMP2 peroxisomal membrane protein 2, 22kDa
S100A8 S100 calcium binding protein A8
SEPW1 selenoprotein W, 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPP1 secreted phosphoprotein 1
SRSF6 serine/arginine-rich splicing factor 6
SYNM synemin, intermediate filament protein
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM14A transmembrane protein 14A
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
VCAN versican
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta