BRD-K76694128_DCC-2036_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

175 genes differentially expressed following the BRD-K76694128_DCC-2036_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ACTA2 actin, alpha 2, smooth muscle, aorta
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
ALDOA aldolase A, fructose-bisphosphate
ANXA4 annexin A4
ARMCX6 armadillo repeat containing, X-linked 6
ATF3 activating transcription factor 3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BEX1 brain expressed, X-linked 1
BEX4 brain expressed, X-linked 4
BTG2 BTG family, member 2
C14ORF132 chromosome 14 open reading frame 132
C9ORF3 chromosome 9 open reading frame 3
CAPN3 calpain 3, (p94)
CCND2 cyclin D2
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHIC2 cysteine-rich hydrophobic domain 2
CKB creatine kinase, brain
CPM carboxypeptidase M
CRABP2 cellular retinoic acid binding protein 2
CRYAB crystallin, alpha B
DCN decorin
DDAH2 dimethylarginine dimethylaminohydrolase 2
DHRS1 dehydrogenase/reductase (SDR family) member 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM134B family with sequence similarity 134, member B
FAM63A family with sequence similarity 63, member A
FBLN5 fibulin 5
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR3 fibroblast growth factor receptor 3
FXYD3 FXYD domain containing ion transport regulator 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GSTA4 glutathione S-transferase alpha 4
GSTP1 glutathione S-transferase pi 1
HOOK2 hook microtubule-tethering protein 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFI6 interferon, alpha-inducible protein 6
KLF4 Kruppel-like factor 4 (gut)
KRT19 keratin 19, type I
LAMP2 lysosomal-associated membrane protein 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRRC17 leucine rich repeat containing 17
LTBP1 latent transforming growth factor beta binding protein 1
LUM lumican
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGED1 melanoma antigen family D1
MAGED2 melanoma antigen family D2
MAN2A1 mannosidase, alpha, class 2A, member 1
MATN2 matrilin 2
MEIS1 Meis homeobox 1
MVP major vault protein
MXRA5 matrix-remodelling associated 5
MYLK myosin light chain kinase
NDRG2 NDRG family member 2
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NREP neuronal regeneration related protein
NSG1 neuron specific gene family member 1
PAMR1 peptidase domain containing associated with muscle regeneration 1
PBLD phenazine biosynthesis-like protein domain containing
PDGFC platelet derived growth factor C
PDIA3 protein disulfide isomerase family A, member 3
PDLIM1 PDZ and LIM domain 1
PEG3 paternally expressed 3
PFDN5 prefoldin subunit 5
PLSCR3 phospholipid scramblase 3
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRAF2 PRA1 domain family, member 2
PRDX2 peroxiredoxin 2
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
PTN pleiotrophin
PTPRC protein tyrosine phosphatase, receptor type, C
PYGL phosphorylase, glycogen, liver
QPRT quinolinate phosphoribosyltransferase
RBP1 retinol binding protein 1, cellular
REC8 REC8 meiotic recombination protein
RGCC regulator of cell cycle
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A4 S100 calcium binding protein A4
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SFTPB surfactant protein B
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC35E3 solute carrier family 35, member E3
SORD sorbitol dehydrogenase
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYT11 synaptotagmin XI
TCEAL4 transcription elongation factor A (SII)-like 4
TCTA T-cell leukemia translocation altered
THBS2 thrombospondin 2
TLE4 transducin-like enhancer of split 4
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TNS1 tensin 1
TPD52L1 tumor protein D52-like 1
TSPAN8 tetraspanin 8
TST thiosulfate sulfurtransferase (rhodanese)
TUBA1A tubulin, alpha 1a
TUG1 taurine up-regulated 1 (non-protein coding)
WDR13 WD repeat domain 13
WDR61 WD repeat domain 61
WFDC1 WAP four-disulfide core domain 1

decreased expression

Symbol Name
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
BAG3 BCL2-associated athanogene 3
BIRC2 baculoviral IAP repeat containing 2
CALML5 calmodulin-like 5
CCDC86 coiled-coil domain containing 86
CCL19 chemokine (C-C motif) ligand 19
CCND1 cyclin D1
CD3EAP CD3e molecule, epsilon associated protein
CDC25A cell division cycle 25A
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL6A2 collagen, type VI, alpha 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPT dermatopontin
DUSP4 dual specificity phosphatase 4
EFHD2 EF-hand domain family, member D2
EIF5A eukaryotic translation initiation factor 5A
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FASN fatty acid synthase
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
GCLM glutamate-cysteine ligase, modifier subunit
GLS glutaminase
GRWD1 glutamate-rich WD repeat containing 1
HIST1H2BG histone cluster 1, H2bg
HSPA1A heat shock 70kDa protein 1A
HSPH1 heat shock 105kDa/110kDa protein 1
IER3 immediate early response 3
IGHM immunoglobulin heavy constant mu
IL1R2 interleukin 1 receptor, type II
KRT7 keratin 7, type II
KRT81 keratin 81, type II
KYNU kynureninase
MMP9 matrix metallopeptidase 9
MOK MOK protein kinase
NNMT nicotinamide N-methyltransferase
NR1H2 nuclear receptor subfamily 1, group H, member 2
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PLAUR plasminogen activator, urokinase receptor
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRR15L proline rich 15-like
PUS7 pseudouridylate synthase 7 (putative)
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB2A2 secretoglobin, family 2A, member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC35F2 solute carrier family 35, member F2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SPRY2 sprouty homolog 2 (Drosophila)
STX1A syntaxin 1A (brain)
TCTN1 tectonic family member 1
TGFB1 transforming growth factor, beta 1
TMEM123 transmembrane protein 123
TMEM2 transmembrane protein 2
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
VDAC1 voltage-dependent anion channel 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon