BRD-K76674262_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

252 genes differentially expressed following the BRD-K76674262_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKAP8 A kinase (PRKA) anchor protein 8
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARHGAP15 Rho GTPase activating protein 15
ARID4B AT rich interactive domain 4B (RBP1-like)
ATAD2B ATPase family, AAA domain containing 2B
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BCL3 B-cell CLL/lymphoma 3
BPTF bromodomain PHD finger transcription factor
BRD2 bromodomain containing 2
C6ORF48 chromosome 6 open reading frame 48
C8ORF4 chromosome 8 open reading frame 4
CADM1 cell adhesion molecule 1
CCL2 chemokine (C-C motif) ligand 2
CCNL1 cyclin L1
CDKN2AIP CDKN2A interacting protein
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLK4 CDC-like kinase 4
CLU clusterin
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DAPK1 death-associated protein kinase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EFNA1 ephrin-A1
EGR1 early growth response 1
EIF5 eukaryotic translation initiation factor 5
FAM13A family with sequence similarity 13, member A
FAM13B family with sequence similarity 13, member B
FNBP4 formin binding protein 4
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GCH1 GTP cyclohydrolase 1
GEM GTP binding protein overexpressed in skeletal muscle
GOLGA4 golgin A4
GTF2H2B general transcription factor IIH, polypeptide 2B (pseudogene)
GUSBP3 glucuronidase, beta pseudogene 3
H2BFS H2B histone family, member S (pseudogene)
H3F3B H3 histone, family 3B (H3.3B)
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BI histone cluster 1, H2bi
HIST1H2BK histone cluster 1, H2bk
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
HOXA5 homeobox A5
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL32 interleukin 32
ING3 inhibitor of growth family, member 3
IRF1 interferon regulatory factor 1
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM6A lysine (K)-specific demethylase 6A
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
KRCC1 lysine-rich coiled-coil 1
KYNU kynureninase
LOC100272216 uncharacterized LOC100272216
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MCL1 myeloid cell leukemia 1
MICU2 mitochondrial calcium uptake 2
MUC5B mucin 5B, oligomeric mucus/gel-forming
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPL1 nucleoporin like 1
PCGF1 polycomb group ring finger 1
PDLIM5 PDZ and LIM domain 5
PELI1 pellino E3 ubiquitin protein ligase 1
PER2 period circadian clock 2
PLAGL1 pleiomorphic adenoma gene-like 1
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
PRPF3 pre-mRNA processing factor 3
PSPC1 paraspeckle component 1
PTBP2 polypyrimidine tract binding protein 2
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RCOR3 REST corepressor 3
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RNFT1 ring finger protein, transmembrane 1
RSRC2 arginine/serine-rich coiled-coil 2
S100A7 S100 calcium binding protein A7
SAT1 spermidine/spermine N1-acetyltransferase 1
SFRP1 secreted frizzled-related protein 1
SLC16A6 solute carrier family 16, member 6
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SMIM7 small integral membrane protein 7
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SOX4 SRY (sex determining region Y)-box 4
SREK1 splicing regulatory glutamine/lysine-rich protein 1
SRSF7 serine/arginine-rich splicing factor 7
SUPT7L suppressor of Ty 7 (S. cerevisiae)-like
SYNGR3 synaptogyrin 3
THUMPD2 THUMP domain containing 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TLK2 tousled-like kinase 2
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIM33 tripartite motif containing 33
TSC22D1 TSC22 domain family, member 1
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B
WSB1 WD repeat and SOCS box containing 1
YPEL5 yippee-like 5 (Drosophila)
YTHDC1 YTH domain containing 1
ZCCHC8 zinc finger, CCHC domain containing 8
ZFP36 ZFP36 ring finger protein
ZMYM2 zinc finger, MYM-type 2
ZMYM5 zinc finger, MYM-type 5

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ADIRF adipogenesis regulatory factor
AHNAK AHNAK nucleoprotein
AHNAK2 AHNAK nucleoprotein 2
ANXA11 annexin A11
AP2B1 adaptor-related protein complex 2, beta 1 subunit
ASS1 argininosuccinate synthase 1
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATP9A ATPase, class II, type 9A
AUTS2 autism susceptibility candidate 2
B3GNT1
BASP1 brain abundant, membrane attached signal protein 1
BCHE butyrylcholinesterase
BIN1 bridging integrator 1
C14ORF132 chromosome 14 open reading frame 132
CANT1 calcium activated nucleotidase 1
CCDC85B coiled-coil domain containing 85B
CCNA2 cyclin A2
CD9 CD9 molecule
CD93 CD93 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CKLF chemokine-like factor
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
CTSB cathepsin B
CTSZ cathepsin Z
DACH1 dachshund family transcription factor 1
DDAH2 dimethylarginine dimethylaminohydrolase 2
DSP desmoplakin
EMP2 epithelial membrane protein 2
ENDOD1 endonuclease domain containing 1
EYA2 EYA transcriptional coactivator and phosphatase 2
FAR2 fatty acyl CoA reductase 2
FCGBP Fc fragment of IgG binding protein
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FEN1 flap structure-specific endonuclease 1
FHL1 four and a half LIM domains 1
GAS6 growth arrest-specific 6
GJA1 gap junction protein, alpha 1, 43kDa
GLUD1 glutamate dehydrogenase 1
GNPDA1 glucosamine-6-phosphate deaminase 1
H2AFX H2A histone family, member X
HMGB3 high mobility group box 3
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HSPA1A heat shock 70kDa protein 1A
IGF1R insulin-like growth factor 1 receptor
IGFBP6 insulin-like growth factor binding protein 6
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INSIG1 insulin induced gene 1
IPO5 importin 5
KANK1 KN motif and ankyrin repeat domains 1
KCTD12 potassium channel tetramerization domain containing 12
LAMP1 lysosomal-associated membrane protein 1
LAMP5 lysosomal-associated membrane protein family, member 5
LGALS4 lectin, galactoside-binding, soluble, 4
LIPA lipase A, lysosomal acid, cholesterol esterase
LMO2 LIM domain only 2 (rhombotin-like 1)
MAT2A methionine adenosyltransferase II, alpha
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MME membrane metallo-endopeptidase
MPPED2 metallophosphoesterase domain containing 2
MRPL11 mitochondrial ribosomal protein L11
MXRA7 matrix-remodelling associated 7
NDRG2 NDRG family member 2
NMU neuromedin U
OLFM4 olfactomedin 4
OLFML3 olfactomedin-like 3
PARP1 poly (ADP-ribose) polymerase 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLBD1 phospholipase B domain containing 1
PODXL podocalyxin-like
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKRIR protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
PRSS23 protease, serine, 23
PSRC1 proline/serine-rich coiled-coil 1
RALGDS ral guanine nucleotide dissociation stimulator
RAP2A RAP2A, member of RAS oncogene family
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RPA1 replication protein A1, 70kDa
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SNN stannin
SPINK4 serine peptidase inhibitor, Kazal type 4
STMN1 stathmin 1
TBC1D16 TBC1 domain family, member 16
TFDP1 transcription factor Dp-1
THAP11 THAP domain containing 11
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TM9SF2 transmembrane 9 superfamily member 2
TMEM109 transmembrane protein 109
TMEM97 transmembrane protein 97
TMSB15A thymosin beta 15a
TNNT1 troponin T type 1 (skeletal, slow)
TPST2 tyrosylprotein sulfotransferase 2
TSPAN13 tetraspanin 13
VAT1 vesicle amine transport 1
YBX3 Y box binding protein 3