BRD-K76401790_JNK-IN-5A_PC3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

158 genes differentially expressed following the BRD-K76401790_JNK-IN-5A_PC3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
AQP3 aquaporin 3 (Gill blood group)
AURKA aurora kinase A
AXL AXL receptor tyrosine kinase
BGN biglycan
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CCND2 cyclin D2
CDA cytidine deaminase
CHIC2 cysteine-rich hydrophobic domain 2
COL9A3 collagen, type IX, alpha 3
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CTGF connective tissue growth factor
CTSZ cathepsin Z
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDAH1 dimethylarginine dimethylaminohydrolase 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLK1 delta-like 1 homolog (Drosophila)
DUSP1 dual specificity phosphatase 1
DUSP22 dual specificity phosphatase 22
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EPAS1 endothelial PAS domain protein 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPN2 epsin 2
F3 coagulation factor III (thromboplastin, tissue factor)
FBN2 fibrillin 2
FGFR3 fibroblast growth factor receptor 3
FSCN1 fascin actin-bundling protein 1
FTSJ1 FtsJ RNA methyltransferase homolog 1 (E. coli)
GADD45B growth arrest and DNA-damage-inducible, beta
HOPX HOP homeobox
HSPA8 heat shock 70kDa protein 8
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KLHDC10 kelch domain containing 10
KRT14 keratin 14, type I
KRT15 keratin 15, type I
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAL mal, T-cell differentiation protein
MT1E metallothionein 1E
OSBPL3 oxysterol binding protein-like 3
PIEZO1 piezo-type mechanosensitive ion channel component 1
PLK1 polo-like kinase 1
PLLP plasmolipin
PLS3 plastin 3
PRDX4 peroxiredoxin 4
PTX3 pentraxin 3, long
REXO2 RNA exonuclease 2
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SATB2 SATB homeobox 2
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMS spermine synthase
SORBS3 sorbin and SH3 domain containing 3
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TAGLN transgelin
THBS1 thrombospondin 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2S ubiquitin-conjugating enzyme E2S
WNT5B wingless-type MMTV integration site family, member 5B
ZBTB16 zinc finger and BTB domain containing 16

decreased expression

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADIRF adipogenesis regulatory factor
AHR aryl hydrocarbon receptor
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AMACR alpha-methylacyl-CoA racemase
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
BCHE butyrylcholinesterase
BCL6 B-cell CLL/lymphoma 6
CCNE2 cyclin E2
CD200 CD200 molecule
CD24 CD24 molecule
CD58 CD58 molecule
CDK1 cyclin-dependent kinase 1
CFB complement factor B
CFI complement factor I
COL3A1 collagen, type III, alpha 1
CREB1 cAMP responsive element binding protein 1
CYB5A cytochrome b5 type A (microsomal)
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DPP4 dipeptidyl-peptidase 4
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
ECHDC2 enoyl CoA hydratase domain containing 2
ETV1 ets variant 1
FAM162A family with sequence similarity 162, member A
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FXYD3 FXYD domain containing ion transport regulator 3
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GAS7 growth arrest-specific 7
GINS1 GINS complex subunit 1 (Psf1 homolog)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HEXB hexosaminidase B (beta polypeptide)
HILPDA hypoxia inducible lipid droplet-associated
HIST1H4C histone cluster 1, H4c
HMGA2 high mobility group AT-hook 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL1B interleukin 1, beta
ITGA7 integrin, alpha 7
KRCC1 lysine-rich coiled-coil 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIG1 ligase I, DNA, ATP-dependent
LOC100505650 uncharacterized LOC100505650
LRRC41 leucine rich repeat containing 41
LUM lumican
MCM6 minichromosome maintenance complex component 6
MTMR11 myotubularin related protein 11
MYLIP myosin regulatory light chain interacting protein
N4BP2L1 NEDD4 binding protein 2-like 1
NAMPT nicotinamide phosphoribosyltransferase
NIT2 nitrilase family, member 2
NPY neuropeptide Y
NREP neuronal regeneration related protein
NRIP1 nuclear receptor interacting protein 1
OLFML2A olfactomedin-like 2A
PCP4 Purkinje cell protein 4
PENK proenkephalin
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLEK pleckstrin
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLIN2 perilipin 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PYCARD PYD and CARD domain containing
REEP1 receptor accessory protein 1
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
S100A8 S100 calcium binding protein A8
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPAG4 sperm associated antigen 4
STEAP1 six transmembrane epithelial antigen of the prostate 1
SYT1 synaptotagmin I
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAPPC3 trafficking protein particle complex 3
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C