BRD-K76401790_JNK-IN-5A_PC3_24_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

165 genes differentially expressed following the BRD-K76401790_JNK-IN-5A_PC3_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANKRD27 ankyrin repeat domain 27 (VPS9 domain)
ARL4A ADP-ribosylation factor-like 4A
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
CAV1 caveolin 1, caveolae protein, 22kDa
CHIC2 cysteine-rich hydrophobic domain 2
COL9A3 collagen, type IX, alpha 3
CPE carboxypeptidase E
CRISP3 cysteine-rich secretory protein 3
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCR4 chemokine (C-X-C motif) receptor 4
DCLK1 doublecortin-like kinase 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP1 dual specificity phosphatase 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPAS1 endothelial PAS domain protein 1
EPCAM epithelial cell adhesion molecule
FGFR2 fibroblast growth factor receptor 2
FTH1 ferritin, heavy polypeptide 1
H2BFS H2B histone family, member S (pseudogene)
HIST1H2BK histone cluster 1, H2bk
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IL7R interleukin 7 receptor
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
KIF20A kinesin family member 20A
KLHL21 kelch-like family member 21
KRT14 keratin 14, type I
LAMP1 lysosomal-associated membrane protein 1
LEF1 lymphoid enhancer-binding factor 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP7 microtubule-associated protein 7
MT1M metallothionein 1M
MTSS1 metastasis suppressor 1
NNMT nicotinamide N-methyltransferase
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PCDH9 protocadherin 9
PDIA3 protein disulfide isomerase family A, member 3
PLK1 polo-like kinase 1
PODXL podocalyxin-like
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PTX3 pentraxin 3, long
RCAN1 regulator of calcineurin 1
RFTN1 raftlin, lipid raft linker 1
S100P S100 calcium binding protein P
SCGB1D2 secretoglobin, family 1D, member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP4 secreted frizzled-related protein 4
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SOX9 SRY (sex determining region Y)-box 9
SPARCL1 SPARC-like 1 (hevin)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TAGLN transgelin
TATDN2 TatD DNase domain containing 2
TCF4 transcription factor 4
TCL1A T-cell leukemia/lymphoma 1A
U2AF1 U2 small nuclear RNA auxiliary factor 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1

decreased expression

Symbol Name
AGA aspartylglucosaminidase
AHR aryl hydrocarbon receptor
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase)
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALOX5 arachidonate 5-lipoxygenase
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA10 annexin A10
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX2 armadillo repeat containing, X-linked 2
ARMCX6 armadillo repeat containing, X-linked 6
ASPH aspartate beta-hydroxylase
BCHE butyrylcholinesterase
BEX4 brain expressed, X-linked 4
CA12 carbonic anhydrase XII
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD58 CD58 molecule
CDK1 cyclin-dependent kinase 1
CFI complement factor I
COPS7A COP9 signalosome subunit 7A
CRABP2 cellular retinoic acid binding protein 2
CREB1 cAMP responsive element binding protein 1
CSTA cystatin A (stefin A)
CTNND1 catenin (cadherin-associated protein), delta 1
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL6 chemokine (C-X-C motif) ligand 6
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DPP4 dipeptidyl-peptidase 4
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
DYNLT3 dynein, light chain, Tctex-type 3
ECHDC2 enoyl CoA hydratase domain containing 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ETV1 ets variant 1
EXOSC4 exosome component 4
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FLRT3 fibronectin leucine rich transmembrane protein 3
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GSPT2 G1 to S phase transition 2
GSTT1 glutathione S-transferase theta 1
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HES1 hes family bHLH transcription factor 1
HK2 hexokinase 2
HLF hepatic leukemia factor
HMGA2 high mobility group AT-hook 2
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KDM5D lysine (K)-specific demethylase 5D
KRT13 keratin 13, type I
KRT19 keratin 19, type I
LAMB1 laminin, beta 1
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LY6E lymphocyte antigen 6 complex, locus E
MAGED1 melanoma antigen family D1
MAPT microtubule-associated protein tau
MCM3 minichromosome maintenance complex component 3
MDK midkine (neurite growth-promoting factor 2)
MTMR11 myotubularin related protein 11
MXRA5 matrix-remodelling associated 5
NID2 nidogen 2 (osteonidogen)
PCBP2 poly(rC) binding protein 2
PCNA proliferating cell nuclear antigen
PCP4 Purkinje cell protein 4
PFKM phosphofructokinase, muscle
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLAC8 placenta-specific 8
PLIN2 perilipin 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RAD51AP1 RAD51 associated protein 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBPMS RNA binding protein with multiple splicing
RNASE4 ribonuclease, RNase A family, 4
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCPEP1 serine carboxypeptidase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELENBP1 selenium binding protein 1
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SPON2 spondin 2, extracellular matrix protein
TACSTD2 tumor-associated calcium signal transducer 2
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TMEM45A transmembrane protein 45A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TOPBP1 topoisomerase (DNA) II binding protein 1
TRIM22 tripartite motif containing 22
TSPAN1 tetraspanin 1
TSPAN6 tetraspanin 6
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WBP5 WW domain binding protein 5
ZBTB20 zinc finger and BTB domain containing 20
ZSCAN18 zinc finger and SCAN domain containing 18