BRD-K76401790_JNK-IN-5A_PC3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

92 genes differentially expressed following the BRD-K76401790_JNK-IN-5A_PC3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AURKA aurora kinase A
BGN biglycan
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CCND2 cyclin D2
CHIC2 cysteine-rich hydrophobic domain 2
CNOT4 CCR4-NOT transcription complex, subunit 4
CPB1 carboxypeptidase B1 (tissue)
CRISP3 cysteine-rich secretory protein 3
CRYAB crystallin, alpha B
CTGF connective tissue growth factor
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DUSP1 dual specificity phosphatase 1
FOLR1 folate receptor 1 (adult)
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GAGE3 G antigen 3
GALC galactosylceramidase
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GAS6 growth arrest-specific 6
GLIPR1 GLI pathogenesis-related 1
GRB10 growth factor receptor-bound protein 10
GSTA1 glutathione S-transferase alpha 1
H2BFS H2B histone family, member S (pseudogene)
HDGFRP3 hepatoma-derived growth factor, related protein 3
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HSPA8 heat shock 70kDa protein 8
IGF1R insulin-like growth factor 1 receptor
IRS2 insulin receptor substrate 2
JMJD6 jumonji domain containing 6
KLHDC10 kelch domain containing 10
KRT14 keratin 14, type I
KRT5 keratin 5, type II
MMP7 matrix metallopeptidase 7
NCK2 NCK adaptor protein 2
OLFM4 olfactomedin 4
PCDH9 protocadherin 9
PDZK1IP1 PDZK1 interacting protein 1
PROM1 prominin 1
PTX3 pentraxin 3, long
RBKS ribokinase
RRAGD Ras-related GTP binding D
RUNX3 runt-related transcription factor 3
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLCO3A1 solute carrier organic anion transporter family, member 3A1
STK26 serine/threonine protein kinase 26
TBL1X transducin (beta)-like 1X-linked
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TRPS1 trichorhinophalangeal syndrome I
VDAC1 voltage-dependent anion channel 1
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
BCHE butyrylcholinesterase
CD58 CD58 molecule
CDK1 cyclin-dependent kinase 1
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CREB1 cAMP responsive element binding protein 1
CST6 cystatin E/M
CYB5A cytochrome b5 type A (microsomal)
ENO2 enolase 2 (gamma, neuronal)
ETV1 ets variant 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM69A family with sequence similarity 69, member A
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FXYD3 FXYD domain containing ion transport regulator 3
GINS1 GINS complex subunit 1 (Psf1 homolog)
HBB hemoglobin, beta
HIST1H4C histone cluster 1, H4c
HOPX HOP homeobox
HOXA10 homeobox A10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
LAMA4 laminin, alpha 4
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MATN2 matrilin 2
PDZD2 PDZ domain containing 2
PLAT plasminogen activator, tissue
PLP1 proteolipid protein 1
RHOBTB3 Rho-related BTB domain containing 3
SHOX2 short stature homeobox 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK1 serine peptidase inhibitor, Kazal type 1
TMEM45A transmembrane protein 45A
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIM22 tripartite motif containing 22
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C