BRD-K76401790_JNK-IN-5A_MCF7_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

231 genes differentially expressed following the BRD-K76401790_JNK-IN-5A_MCF7_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACSL1 acyl-CoA synthetase long-chain family member 1
ACTN1 actinin, alpha 1
AKAP8L A kinase (PRKA) anchor protein 8-like
ANGPT1 angiopoietin 1
ATP5H ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d
AURKA aurora kinase A
AXIN1 axin 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CAPN2 calpain 2, (m/II) large subunit
CCL5 chemokine (C-C motif) ligand 5
CD27 CD27 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CLGN calmegin
CLU clusterin
COCH cochlin
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYR61 cysteine-rich, angiogenic inducer, 61
CYTIP cytohesin 1 interacting protein
DUSP1 dual specificity phosphatase 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPHA2 EPH receptor A2
FBL fibrillarin
FOSL1 FOS-like antigen 1
FSCN1 fascin actin-bundling protein 1
GLIPR1 GLI pathogenesis-related 1
HIST2H2BE histone cluster 2, H2be
IFI30 interferon, gamma-inducible protein 30
IGHA1 immunoglobulin heavy constant alpha 1
IGHM immunoglobulin heavy constant mu
INHBB inhibin, beta B
ITGA6 integrin, alpha 6
ITGB5 integrin, beta 5
JMJD6 jumonji domain containing 6
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
LTF lactotransferrin
MBNL2 muscleblind-like splicing regulator 2
MPHOSPH6 M-phase phosphoprotein 6
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
NELL2 NEL-like 2 (chicken)
NOSIP nitric oxide synthase interacting protein
NTS neurotensin
P3H2 prolyl 3-hydroxylase 2
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PERP PERP, TP53 apoptosis effector
PHF1 PHD finger protein 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIP prolactin-induced protein
PLBD1 phospholipase B domain containing 1
PLCB4 phospholipase C, beta 4
PLK2 polo-like kinase 2
PODXL podocalyxin-like
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRR7 proline rich 7 (synaptic)
PTRF polymerase I and transcript release factor
RALB v-ral simian leukemia viral oncogene homolog B
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM25 RNA binding motif protein 25
RGCC regulator of cell cycle
RND3 Rho family GTPase 3
RNF130 ring finger protein 130
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A10 S100 calcium binding protein A10
S100A12 S100 calcium binding protein A12
S100A9 S100 calcium binding protein A9
SDC3 syndecan 3
SFN stratifin
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SMAD3 SMAD family member 3
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SPRR1A small proline-rich protein 1A
TARP TCR gamma alternate reading frame protein
TBC1D4 TBC1 domain family, member 4
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TCL1A T-cell leukemia/lymphoma 1A
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPM1 tropomyosin 1 (alpha)
TRAC T cell receptor alpha constant
TRD T cell receptor delta locus
TRIM2 tripartite motif containing 2
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
YBX3 Y box binding protein 3

decreased expression

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AHR aryl hydrocarbon receptor
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
AMACR alpha-methylacyl-CoA racemase
ANXA9 annexin A9
ARMCX2 armadillo repeat containing, X-linked 2
ARMCX3 armadillo repeat containing, X-linked 3
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BEX4 brain expressed, X-linked 4
BNC2 basonuclin 2
C14ORF132 chromosome 14 open reading frame 132
CA12 carbonic anhydrase XII
CAPN1 calpain 1, (mu/I) large subunit
CBX5 chromobox homolog 5
CCNE2 cyclin E2
CCNF cyclin F
CD99 CD99 molecule
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CGRRF1 cell growth regulator with ring finger domain 1
CHEK2 checkpoint kinase 2
CTSK cathepsin K
CXCL12 chemokine (C-X-C motif) ligand 12
DACT1 dishevelled-binding antagonist of beta-catenin 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEPTOR DEP domain containing MTOR-interacting protein
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPT dermatopontin
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EAPP E2F-associated phosphoprotein
ESR1 estrogen receptor 1
FAM134B family with sequence similarity 134, member B
FAM63A family with sequence similarity 63, member A
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FMO5 flavin containing monooxygenase 5
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GATA3 GATA binding protein 3
GINS1 GINS complex subunit 1 (Psf1 homolog)
GLS glutaminase
GNPDA1 glucosamine-6-phosphate deaminase 1
GSPT2 G1 to S phase transition 2
H2AFX H2A histone family, member X
HADH hydroxyacyl-CoA dehydrogenase
HILPDA hypoxia inducible lipid droplet-associated
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H')
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI44L interferon-induced protein 44-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IGF1R insulin-like growth factor 1 receptor
IGFBP4 insulin-like growth factor binding protein 4
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
IL1R1 interleukin 1 receptor, type I
ITM2A integral membrane protein 2A
KDM5D lysine (K)-specific demethylase 5D
KIAA0101 KIAA0101
KLK5 kallikrein-related peptidase 5
LAMP5 lysosomal-associated membrane protein family, member 5
LGALS3 lectin, galactoside-binding, soluble, 3
LOC100505650 uncharacterized LOC100505650
MAGED1 melanoma antigen family D1
MAOA monoamine oxidase A
MAP2K6 mitogen-activated protein kinase kinase 6
MAPT microtubule-associated protein tau
MBP myelin basic protein
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MFAP4 microfibrillar-associated protein 4
MFAP5 microfibrillar associated protein 5
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUC1 mucin 1, cell surface associated
NET1 neuroepithelial cell transforming 1
NLRP2 NLR family, pyrin domain containing 2
NQO1 NAD(P)H dehydrogenase, quinone 1
NR1H2 nuclear receptor subfamily 1, group H, member 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
OLFML2A olfactomedin-like 2A
OLFML3 olfactomedin-like 3
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PCBP2 poly(rC) binding protein 2
PCNA proliferating cell nuclear antigen
PDE1A phosphodiesterase 1A, calmodulin-dependent
PDGFRL platelet-derived growth factor receptor-like
PLAGL1 pleiomorphic adenoma gene-like 1
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PTGES prostaglandin E synthase
RBM47 RNA binding motif protein 47
RHOBTB3 Rho-related BTB domain containing 3
RNASE4 ribonuclease, RNase A family, 4
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM2 ribonucleotide reductase M2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SFRP4 secreted frizzled-related protein 4
SIAH2 siah E3 ubiquitin protein ligase 2
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SOX4 SRY (sex determining region Y)-box 4
SSPN sarcospan
STAG2 stromal antigen 2
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
THBS2 thrombospondin 2
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TMEM243 transmembrane protein 243, mitochondrial
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TPD52L1 tumor protein D52-like 1
TSPAN6 tetraspanin 6
TUBB tubulin, beta class I
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VIM vimentin
VLDLR very low density lipoprotein receptor
ZWINT ZW10 interacting kinetochore protein