BRD-K76401790_JNK-IN-5A_MCF7_24_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

185 genes differentially expressed following the BRD-K76401790_JNK-IN-5A_MCF7_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACSL1 acyl-CoA synthetase long-chain family member 1
AKAP8L A kinase (PRKA) anchor protein 8-like
ATRX alpha thalassemia/mental retardation syndrome X-linked
AURKA aurora kinase A
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CAPN2 calpain 2, (m/II) large subunit
CCL5 chemokine (C-C motif) ligand 5
CD8A CD8a molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CENPE centromere protein E, 312kDa
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
COCH cochlin
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CTSL cathepsin L
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DACH1 dachshund family transcription factor 1
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
EPHA2 EPH receptor A2
FOSL1 FOS-like antigen 1
HIST1H1C histone cluster 1, H1c
HIST1H2BC histone cluster 1, H2bc
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
HSPA4L heat shock 70kDa protein 4-like
IER5 immediate early response 5
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGHM immunoglobulin heavy constant mu
IL7R interleukin 7 receptor
JMJD6 jumonji domain containing 6
KIAA0226L KIAA0226-like
KIF20A kinesin family member 20A
KLRK1 killer cell lectin-like receptor subfamily K, member 1
LGALS4 lectin, galactoside-binding, soluble, 4
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MBNL2 muscleblind-like splicing regulator 2
MTSS1 metastasis suppressor 1
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NEFH neurofilament, heavy polypeptide
NELL2 NEL-like 2 (chicken)
NFE2L3 nuclear factor, erythroid 2-like 3
NTS neurotensin
P3H2 prolyl 3-hydroxylase 2
PCDH9 protocadherin 9
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLBD1 phospholipase B domain containing 1
PLCB4 phospholipase C, beta 4
PODXL podocalyxin-like
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRR7 proline rich 7 (synaptic)
RBM25 RNA binding motif protein 25
RND3 Rho family GTPase 3
S100A12 S100 calcium binding protein A12
S100P S100 calcium binding protein P
SFN stratifin
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SOCS2 suppressor of cytokine signaling 2
TARP TCR gamma alternate reading frame protein
TCL1A T-cell leukemia/lymphoma 1A
TGFA transforming growth factor, alpha
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
TNIK TRAF2 and NCK interacting kinase
TRAC T cell receptor alpha constant
TRD T cell receptor delta locus
TRIM2 tripartite motif containing 2
TUBB2A tubulin, beta 2A class IIa
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
XIST X inactive specific transcript (non-protein coding)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AHCY adenosylhomocysteinase
AHR aryl hydrocarbon receptor
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ARMCX2 armadillo repeat containing, X-linked 2
ARMCX3 armadillo repeat containing, X-linked 3
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
C3 complement component 3
CADM1 cell adhesion molecule 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPN1 calpain 1, (mu/I) large subunit
CCNE2 cyclin E2
CCNF cyclin F
CD99 CD99 molecule
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CFB complement factor B
CGRRF1 cell growth regulator with ring finger domain 1
COL14A1 collagen, type XIV, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CXCL12 chemokine (C-X-C motif) ligand 12
DCAF10 DDB1 and CUL4 associated factor 10
DEPTOR DEP domain containing MTOR-interacting protein
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EAPP E2F-associated phosphoprotein
ESR1 estrogen receptor 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FADS1 fatty acid desaturase 1
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GATA3 GATA binding protein 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GNPDA1 glucosamine-6-phosphate deaminase 1
GPNMB glycoprotein (transmembrane) nmb
HADH hydroxyacyl-CoA dehydrogenase
HAPLN1 hyaluronan and proteoglycan link protein 1
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFITM1 interferon induced transmembrane protein 1
IGFBP4 insulin-like growth factor binding protein 4
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
IL1R1 interleukin 1 receptor, type I
ITM2A integral membrane protein 2A
JCHAIN joining chain of multimeric IgA and IgM
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KIAA0101 KIAA0101
KLK5 kallikrein-related peptidase 5
MAP2K6 mitogen-activated protein kinase kinase 6
MAPT microtubule-associated protein tau
MBP myelin basic protein
MCM6 minichromosome maintenance complex component 6
MDK midkine (neurite growth-promoting factor 2)
MFAP4 microfibrillar-associated protein 4
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUC1 mucin 1, cell surface associated
MYH10 myosin, heavy chain 10, non-muscle
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NET1 neuroepithelial cell transforming 1
NREP neuronal regeneration related protein
NUSAP1 nucleolar and spindle associated protein 1
OLFML2A olfactomedin-like 2A
OLFML3 olfactomedin-like 3
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R3C protein phosphatase 1, regulatory subunit 3C
QPCT glutaminyl-peptide cyclotransferase
RARA retinoic acid receptor, alpha
RBM15B RNA binding motif protein 15B
RNASE4 ribonuclease, RNase A family, 4
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM2 ribonucleotide reductase M2
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
S100A6 S100 calcium binding protein A6
SCGB1D2 secretoglobin, family 1D, member 2
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP4 secreted frizzled-related protein 4
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SPINK1 serine peptidase inhibitor, Kazal type 1
SSPN sarcospan
SST somatostatin
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
THBS2 thrombospondin 2
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN6 tetraspanin 6
TUBB tubulin, beta class I
TXNDC9 thioredoxin domain containing 9
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAT1 vesicle amine transport 1
WFDC2 WAP four-disulfide core domain 2
ZWINT ZW10 interacting kinetochore protein