BRD-K76401790_JNK-IN-5A_MCF7_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

110 genes differentially expressed following the BRD-K76401790_JNK-IN-5A_MCF7_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AKAP8L A kinase (PRKA) anchor protein 8-like
AMOTL2 angiomotin like 2
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
C14ORF2 chromosome 14 open reading frame 2
CALB1 calbindin 1, 28kDa
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHGB chromogranin B
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CTGF connective tissue growth factor
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
EPAS1 endothelial PAS domain protein 1
FNBP1 formin binding protein 1
FOSL1 FOS-like antigen 1
GNAS GNAS complex locus
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HIST2H2BE histone cluster 2, H2be
HIST3H2A histone cluster 3, H2a
HOXB2 homeobox B2
KYNU kynureninase
LYPD1 LY6/PLAUR domain containing 1
MAL mal, T-cell differentiation protein
MMP10 matrix metallopeptidase 10
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NCAM1 neural cell adhesion molecule 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK2 polo-like kinase 2
PPP1R13B protein phosphatase 1, regulatory subunit 13B
RND3 Rho family GTPase 3
SCD5 stearoyl-CoA desaturase 5
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORBS2 sorbin and SH3 domain containing 2
TCTA T-cell leukemia translocation altered
TGFA transforming growth factor, alpha
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIM2 tripartite motif containing 2
TUBB2A tubulin, beta 2A class IIa
XIST X inactive specific transcript (non-protein coding)
ZMYM2 zinc finger, MYM-type 2

decreased expression

Symbol Name
AKR1C3 aldo-keto reductase family 1, member C3
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ASPN asporin
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
CADM1 cell adhesion molecule 1
CCNF cyclin F
CDK1 cyclin-dependent kinase 1
CHEK2 checkpoint kinase 2
COPS7A COP9 signalosome subunit 7A
CTSK cathepsin K
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DPT dermatopontin
DPYSL2 dihydropyrimidinase-like 2
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EAPP E2F-associated phosphoprotein
FAM129A family with sequence similarity 129, member A
FAP fibroblast activation protein, alpha
FEN1 flap structure-specific endonuclease 1
FMO5 flavin containing monooxygenase 5
GGCT gamma-glutamylcyclotransferase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GPC3 glypican 3
HEBP1 heme binding protein 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
LMO4 LIM domain only 4
MFAP2 microfibrillar-associated protein 2
NR1H2 nuclear receptor subfamily 1, group H, member 2
NREP neuronal regeneration related protein
PDLIM1 PDZ and LIM domain 1
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PROSC proline synthetase co-transcribed homolog (bacterial)
PSPH phosphoserine phosphatase
RBBP8 retinoblastoma binding protein 8
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM2 ribonucleotide reductase M2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SIAH2 siah E3 ubiquitin protein ligase 2
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SPTSSA serine palmitoyltransferase, small subunit A
TAGLN2 transgelin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TOP2A topoisomerase (DNA) II alpha 170kDa
UBE2C ubiquitin-conjugating enzyme E2C
VDAC1 voltage-dependent anion channel 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
ZWINT ZW10 interacting kinetochore protein