BRD-K76401790_JNK-IN-5A_HT29_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

147 genes differentially expressed following the BRD-K76401790_JNK-IN-5A_HT29_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM9 ADAM metallopeptidase domain 9
AURKA aurora kinase A
CAB39 calcium binding protein 39
CAPN2 calpain 2, (m/II) large subunit
CAV2 caveolin 2
CD9 CD9 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CERS6 ceramide synthase 6
COL18A1 collagen, type XVIII, alpha 1
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CXADR coxsackie virus and adenovirus receptor
CYR61 cysteine-rich, angiogenic inducer, 61
DHCR7 7-dehydrocholesterol reductase
DIO2 deiodinase, iodothyronine, type II
ELOVL5 ELOVL fatty acid elongase 5
EPCAM epithelial cell adhesion molecule
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FADS2 fatty acid desaturase 2
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FSTL1 follistatin-like 1
GAL galanin/GMAP prepropeptide
GREM1 gremlin 1, DAN family BMP antagonist
HBEGF heparin-binding EGF-like growth factor
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IGFBP7 insulin-like growth factor binding protein 7
INHBB inhibin, beta B
KIF20A kinesin family member 20A
KLK10 kallikrein-related peptidase 10
LAMA3 laminin, alpha 3
LAMP1 lysosomal-associated membrane protein 1
LDLR low density lipoprotein receptor
LEF1 lymphoid enhancer-binding factor 1
MACF1 microtubule-actin crosslinking factor 1
MICALL1 MICAL-like 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1H metallothionein 1H
MT1X metallothionein 1X
NELL2 NEL-like 2 (chicken)
OSBPL10 oxysterol binding protein-like 10
PAWR PRKC, apoptosis, WT1, regulator
PFKP phosphofructokinase, platelet
PPL periplakin
PRSS23 protease, serine, 23
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
THBS1 thrombospondin 1
TIMP1 TIMP metallopeptidase inhibitor 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRH thyrotropin-releasing hormone
TRIB2 tribbles pseudokinase 2
UBE2S ubiquitin-conjugating enzyme E2S
VSNL1 visinin-like 1

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADD3 adducin 3 (gamma)
ADGRE5 adhesion G protein-coupled receptor E5
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANK2 ankyrin 2, neuronal
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA4 annexin A4
AQP1 aquaporin 1 (Colton blood group)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BIN1 bridging integrator 1
C10ORF10 chromosome 10 open reading frame 10
C1QA complement component 1, q subcomponent, A chain
C1S complement component 1, s subcomponent
C8ORF4 chromosome 8 open reading frame 4
CA12 carbonic anhydrase XII
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CALB1 calbindin 1, 28kDa
CDK1 cyclin-dependent kinase 1
CECR1 cat eye syndrome chromosome region, candidate 1
CHEK2 checkpoint kinase 2
COL3A1 collagen, type III, alpha 1
CRYL1 crystallin, lambda 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL5 chemokine (C-X-C motif) ligand 5
CYBA cytochrome b-245, alpha polypeptide
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAPK1 death-associated protein kinase 1
DCN decorin
DEFB1 defensin, beta 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP6 dual specificity phosphatase 6
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
F13A1 coagulation factor XIII, A1 polypeptide
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM107A family with sequence similarity 107, member A
FAR2 fatty acyl CoA reductase 2
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPX2 glutathione peroxidase 2
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT19 keratin 19, type I
KRT23 keratin 23, type I
LRRC17 leucine rich repeat containing 17
LUM lumican
MAP1A microtubule-associated protein 1A
MARCKS myristoylated alanine-rich protein kinase C substrate
MBP myelin basic protein
MFAP4 microfibrillar-associated protein 4
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
P2RY14 purinergic receptor P2Y, G-protein coupled, 14
PENK proenkephalin
PLIN2 perilipin 2
PRKCD protein kinase C, delta
RECQL RecQ helicase-like
RGS2 regulator of G-protein signaling 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SLC17A3 solute carrier family 17 (organic anion transporter), member 3
SMAD1 SMAD family member 1
SOX4 SRY (sex determining region Y)-box 4
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STMN2 stathmin 2
TFPI2 tissue factor pathway inhibitor 2
TMEM176A transmembrane protein 176A
TMEM45A transmembrane protein 45A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIB1 tribbles pseudokinase 1
TXNIP thioredoxin interacting protein
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VCAM1 vascular cell adhesion molecule 1
VCAN versican