BRD-K76401790_JNK-IN-5A_HT29_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

150 genes differentially expressed following the BRD-K76401790_JNK-IN-5A_HT29_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANXA3 annexin A3
AURKA aurora kinase A
AXL AXL receptor tyrosine kinase
BAMBI BMP and activin membrane-bound inhibitor
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCND2 cyclin D2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC20 cell division cycle 20
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLIC3 chloride intracellular channel 3
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
COL10A1 collagen, type X, alpha 1
COL4A2 collagen, type IV, alpha 2
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CTGF connective tissue growth factor
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DLK1 delta-like 1 homolog (Drosophila)
DSG3 desmoglein 3
DST dystonin
EDN3 endothelin 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELANE elastase, neutrophil expressed
F3 coagulation factor III (thromboplastin, tissue factor)
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FSTL1 follistatin-like 1
GPM6B glycoprotein M6B
HBEGF heparin-binding EGF-like growth factor
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOOK2 hook microtubule-tethering protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP7 insulin-like growth factor binding protein 7
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLV2-23 immunoglobulin lambda variable 2-23
INHBB inhibin, beta B
IRS2 insulin receptor substrate 2
KIF20A kinesin family member 20A
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT7 keratin 7, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LHFP lipoma HMGIC fusion partner
LRP4 low density lipoprotein receptor-related protein 4
LTF lactotransferrin
MATN2 matrilin 2
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MYB v-myb avian myeloblastosis viral oncogene homolog
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NELL2 NEL-like 2 (chicken)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OBSL1 obscurin-like 1
PDZD8 PDZ domain containing 8
PODXL podocalyxin-like
POSTN periostin, osteoblast specific factor
PRDX2 peroxiredoxin 2
PTPRE protein tyrosine phosphatase, receptor type, E
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
S100A2 S100 calcium binding protein A2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SFN stratifin
SLPI secretory leukocyte peptidase inhibitor
STAR steroidogenic acute regulatory protein
STC2 stanniocalcin 2
STEAP3 STEAP family member 3, metalloreductase
SYBU syntabulin (syntaxin-interacting)
TACSTD2 tumor-associated calcium signal transducer 2
TIMP1 TIMP metallopeptidase inhibitor 1
TRIB2 tribbles pseudokinase 2
TRIM29 tripartite motif containing 29
UBE2S ubiquitin-conjugating enzyme E2S
USP6NL USP6 N-terminal like
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
AKR1C3 aldo-keto reductase family 1, member C3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BCHE butyrylcholinesterase
CA12 carbonic anhydrase XII
CD200 CD200 molecule
CDK1 cyclin-dependent kinase 1
CFLAR CASP8 and FADD-like apoptosis regulator
CHEK2 checkpoint kinase 2
CLTA clathrin, light chain A
COL1A1 collagen, type I, alpha 1
CXCL5 chemokine (C-X-C motif) ligand 5
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
EMX2 empty spiracles homeobox 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FXYD2 FXYD domain containing ion transport regulator 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPX2 glutathione peroxidase 2
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HBB hemoglobin, beta
HILPDA hypoxia inducible lipid droplet-associated
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
MELK maternal embryonic leucine zipper kinase
MFAP4 microfibrillar-associated protein 4
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYRF myelin regulatory factor
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGRN neugrin, neurite outgrowth associated
NID2 nidogen 2 (osteonidogen)
PLIN2 perilipin 2
PRKCD protein kinase C, delta
PSPH phosphoserine phosphatase
QPCT glutaminyl-peptide cyclotransferase
REEP1 receptor accessory protein 1
RGS2 regulator of G-protein signaling 2
RNASE4 ribonuclease, RNase A family, 4
RNMT RNA (guanine-7-) methyltransferase
RPS4Y1 ribosomal protein S4, Y-linked 1
SEPP1 selenoprotein P, plasma, 1
SLC17A3 solute carrier family 17 (organic anion transporter), member 3
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SPINK1 serine peptidase inhibitor, Kazal type 1
SV2C synaptic vesicle glycoprotein 2C
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TFPI2 tissue factor pathway inhibitor 2
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMSB15A thymosin beta 15a
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN8 tetraspanin 8
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VCAM1 vascular cell adhesion molecule 1