BRD-K76401790_JNK-IN-5A_HEPG2_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

80 genes differentially expressed following the BRD-K76401790_JNK-IN-5A_HEPG2_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AMIGO2 adhesion molecule with Ig-like domain 2
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCL19 chemokine (C-C motif) ligand 19
CCL5 chemokine (C-C motif) ligand 5
CCND2 cyclin D2
CD3D CD3d molecule, delta (CD3-TCR complex)
CD8A CD8a molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CST3 cystatin C
CST7 cystatin F (leukocystatin)
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
DNM1L dynamin 1-like
EN1 engrailed homeobox 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FAM129A family with sequence similarity 129, member A
FHL1 four and a half LIM domains 1
FILIP1L filamin A interacting protein 1-like
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMK granzyme K (granzyme 3; tryptase II)
HOMER1 homer scaffolding protein 1
IGHM immunoglobulin heavy constant mu
IGLV3-19 immunoglobulin lambda variable 3-19
KAT2B K(lysine) acetyltransferase 2B
LAP3 leucine aminopeptidase 3
LOXL1 lysyl oxidase-like 1
LRP10 low density lipoprotein receptor-related protein 10
MICALL1 MICAL-like 1
MMP9 matrix metallopeptidase 9
MXRA7 matrix-remodelling associated 7
PDGFC platelet derived growth factor C
PDZK1IP1 PDZK1 interacting protein 1
PFN2 profilin 2
SPINK1 serine peptidase inhibitor, Kazal type 1
TIMP1 TIMP metallopeptidase inhibitor 1
TLR4 toll-like receptor 4
TOX3 TOX high mobility group box family member 3
TRBC1 T cell receptor beta constant 1
WSB2 WD repeat and SOCS box containing 2
XIST X inactive specific transcript (non-protein coding)
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDK1 cyclin-dependent kinase 1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CRIP1 cysteine-rich protein 1 (intestinal)
CSTA cystatin A (stefin A)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EMX2 empty spiracles homeobox 2
FADS1 fatty acid desaturase 1
FAM134B family with sequence similarity 134, member B
FCGBP Fc fragment of IgG binding protein
HK2 hexokinase 2
HMGA2 high mobility group AT-hook 2
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
KDM5D lysine (K)-specific demethylase 5D
KRT13 keratin 13, type I
KRT15 keratin 15, type I
MAL mal, T-cell differentiation protein
MOXD1 monooxygenase, DBH-like 1
MUC4 mucin 4, cell surface associated
NREP neuronal regeneration related protein
OLFML2A olfactomedin-like 2A
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PLAC8 placenta-specific 8
PSIP1 PC4 and SFRS1 interacting protein 1
RELN reelin
RNASE4 ribonuclease, RNase A family, 4
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLPI secretory leukocyte peptidase inhibitor
TOP2A topoisomerase (DNA) II alpha 170kDa
UBE2C ubiquitin-conjugating enzyme E2C
WFDC2 WAP four-disulfide core domain 2