BRD-K76401790_JNK-IN-5A_HCC515_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

97 genes differentially expressed following the BRD-K76401790_JNK-IN-5A_HCC515_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APOD apolipoprotein D
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
CASP10 caspase 10, apoptosis-related cysteine peptidase
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSRP1 cysteine and glycine-rich protein 1
CTGF connective tissue growth factor
CXCL3 chemokine (C-X-C motif) ligand 3
CYR61 cysteine-rich, angiogenic inducer, 61
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
EPHB2 EPH receptor B2
FOSL1 FOS-like antigen 1
GBP1 guanylate binding protein 1, interferon-inducible
GLIPR1 GLI pathogenesis-related 1
GREB1 growth regulation by estrogen in breast cancer 1
H2AFV H2A histone family, member V
H3F3B H3 histone, family 3B (H3.3B)
HIST2H2BE histone cluster 2, H2be
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
ITGA6 integrin, alpha 6
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
MTA1 metastasis associated 1
NANOG Nanog homeobox
NDC80 NDC80 kinetochore complex component
PARP2 poly (ADP-ribose) polymerase 2
PDGFA platelet-derived growth factor alpha polypeptide
PIEZO1 piezo-type mechanosensitive ion channel component 1
PIP prolactin-induced protein
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLK1 polo-like kinase 1
PODXL podocalyxin-like
PRC1 protein regulator of cytokinesis 1
PSRC1 proline/serine-rich coiled-coil 1
SDC2 syndecan 2
TPM1 tropomyosin 1 (alpha)
UBE2S ubiquitin-conjugating enzyme E2S
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APP amyloid beta (A4) precursor protein
ARL4C ADP-ribosylation factor-like 4C
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
C10ORF10 chromosome 10 open reading frame 10
CA12 carbonic anhydrase XII
CD36 CD36 molecule (thrombospondin receptor)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
COL3A1 collagen, type III, alpha 1
CYB5A cytochrome b5 type A (microsomal)
EGFL6 EGF-like-domain, multiple 6
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGFR2 fibroblast growth factor receptor 2
GCLC glutamate-cysteine ligase, catalytic subunit
GSTA4 glutathione S-transferase alpha 4
GSTM3 glutathione S-transferase mu 3 (brain)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HES1 hes family bHLH transcription factor 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGKC immunoglobulin kappa constant
IL1R1 interleukin 1 receptor, type I
KRT19 keratin 19, type I
LAMP3 lysosomal-associated membrane protein 3
LOX lysyl oxidase
LXN latexin
MRC2 mannose receptor, C type 2
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NQO1 NAD(P)H dehydrogenase, quinone 1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
POSTN periostin, osteoblast specific factor
PRDX2 peroxiredoxin 2
S100P S100 calcium binding protein P
SELENBP1 selenium binding protein 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFN stratifin
SFTPB surfactant protein B
SOX4 SRY (sex determining region Y)-box 4
SRGN serglycin
STC2 stanniocalcin 2
TFRC transferrin receptor
TPD52L1 tumor protein D52-like 1
TSC22D1 TSC22 domain family, member 1