BRD-K76401790_JNK-IN-5A_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

101 genes differentially expressed following the BRD-K76401790_JNK-IN-5A_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
BCAT1 branched chain amino-acid transaminase 1, cytosolic
CCNA1 cyclin A1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CHGA chromogranin A
EMP1 epithelial membrane protein 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FCMR Fc fragment of IgM receptor
FOLR1 folate receptor 1 (adult)
GAS2L1 growth arrest-specific 2 like 1
GUSBP11 glucuronidase, beta pseudogene 11
H2BFS H2B histone family, member S (pseudogene)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
IL13RA2 interleukin 13 receptor, alpha 2
JCHAIN joining chain of multimeric IgA and IgM
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
NELL2 NEL-like 2 (chicken)
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NRGN neurogranin (protein kinase C substrate, RC3)
PDLIM1 PDZ and LIM domain 1
PECR peroxisomal trans-2-enoyl-CoA reductase
PF4 platelet factor 4
POU2AF1 POU class 2 associating factor 1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RBP4 retinol binding protein 4, plasma
RGS4 regulator of G-protein signaling 4
RTN1 reticulon 1
SCG2 secretogranin II
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
STX1A syntaxin 1A (brain)
TM4SF1 transmembrane 4 L six family member 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSC22D1 TSC22 domain family, member 1
WASF3 WAS protein family, member 3
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BTG1 B-cell translocation gene 1, anti-proliferative
CALR calreticulin
CAPN6 calpain 6
CD24 CD24 molecule
CDK1 cyclin-dependent kinase 1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CELF2 CUGBP, Elav-like family member 2
COL3A1 collagen, type III, alpha 1
CXCL6 chemokine (C-X-C motif) ligand 6
DARS aspartyl-tRNA synthetase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
HBB hemoglobin, beta
HOXA10 homeobox A10
IGFBP3 insulin-like growth factor binding protein 3
KRT13 keratin 13, type I
KRT7 keratin 7, type II
LTF lactotransferrin
MGP matrix Gla protein
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
OLFML3 olfactomedin-like 3
PDE4B phosphodiesterase 4B, cAMP-specific
PDZK1IP1 PDZK1 interacting protein 1
PGAM1 phosphoglycerate mutase 1 (brain)
PGM1 phosphoglucomutase 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PPAP2B phosphatidic acid phosphatase type 2B
PROM1 prominin 1
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCUBE2 signal peptide, CUB domain, EGF-like 2
SRGN serglycin
SRSF7 serine/arginine-rich splicing factor 7
TACSTD2 tumor-associated calcium signal transducer 2
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TMEM45A transmembrane protein 45A
TMEM97 transmembrane protein 97
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
UBE2A ubiquitin-conjugating enzyme E2A
WEE1 WEE1 G2 checkpoint kinase
WFDC2 WAP four-disulfide core domain 2
ZCCHC24 zinc finger, CCHC domain containing 24