BRD-K76401790_JNK-IN-5A_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

76 genes differentially expressed following the BRD-K76401790_JNK-IN-5A_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTN1 actinin, alpha 1
ANXA10 annexin A10
CCND1 cyclin D1
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CLEC2B C-type lectin domain family 2, member B
COL4A5 collagen, type IV, alpha 5
EXOSC4 exosome component 4
FOSL1 FOS-like antigen 1
H2BFS H2B histone family, member S (pseudogene)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BK histone cluster 1, H2bk
ITGA6 integrin, alpha 6
KRT18 keratin 18, type I
MELK maternal embryonic leucine zipper kinase
OAT ornithine aminotransferase
PDLIM1 PDZ and LIM domain 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
SQSTM1 sequestosome 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

decreased expression

Symbol Name
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
C14ORF132 chromosome 14 open reading frame 132
CALR calreticulin
CCNG2 cyclin G2
CD200 CD200 molecule
CD24 CD24 molecule
CDC25B cell division cycle 25B
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDK1 cyclin-dependent kinase 1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHRDL1 chordin-like 1
CRNN cornulin
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ESR1 estrogen receptor 1
GPX3 glutathione peroxidase 3
HILPDA hypoxia inducible lipid droplet-associated
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXA10 homeobox A10
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
KRT13 keratin 13, type I
LMCD1 LIM and cysteine-rich domains 1
MAB21L1 mab-21-like 1 (C. elegans)
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MARCKSL1 MARCKS-like 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NME4 NME/NM23 nucleoside diphosphate kinase 4
NREP neuronal regeneration related protein
OLFML2A olfactomedin-like 2A
OLFML3 olfactomedin-like 3
OSR2 odd-skipped related transciption factor 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCP4 Purkinje cell protein 4
PDZRN3 PDZ domain containing ring finger 3
RHCG Rh family, C glycoprotein
RHOB ras homolog family member B
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A2 secretoglobin, family 2A, member 2
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SOX4 SRY (sex determining region Y)-box 4
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VLDLR very low density lipoprotein receptor