BRD-K76401790_JNK-IN-5A_HA1E_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

86 genes differentially expressed following the BRD-K76401790_JNK-IN-5A_HA1E_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTN1 actinin, alpha 1
BCLAF1 BCL2-associated transcription factor 1
CA2 carbonic anhydrase II
CD52 CD52 molecule
CD9 CD9 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
COCH cochlin
CXCL8 chemokine (C-X-C motif) ligand 8
FAR2 fatty acyl CoA reductase 2
FOSL1 FOS-like antigen 1
H2BFS H2B histone family, member S (pseudogene)
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HEATR1 HEAT repeat containing 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLX H2.0-like homeobox
HSPA8 heat shock 70kDa protein 8
IGHM immunoglobulin heavy constant mu
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MMP9 matrix metallopeptidase 9
MNAT1 MNAT CDK-activating kinase assembly factor 1
NCK2 NCK adaptor protein 2
NPTX2 neuronal pentraxin II
PHLDA1 pleckstrin homology-like domain, family A, member 1
PNP purine nucleoside phosphorylase
RGCC regulator of cell cycle
S100A12 S100 calcium binding protein A12
SEPP1 selenoprotein P, plasma, 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
TCL1A T-cell leukemia/lymphoma 1A

decreased expression

Symbol Name
ADAM12 ADAM metallopeptidase domain 12
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
BHLHE40 basic helix-loop-helix family, member e40
CADM1 cell adhesion molecule 1
CCL4 chemokine (C-C motif) ligand 4
CCNF cyclin F
CD200 CD200 molecule
CD24 CD24 molecule
CHSY1 chondroitin sulfate synthase 1
COL1A1 collagen, type I, alpha 1
DEFB1 defensin, beta 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ENOSF1 enolase superfamily member 1
GADD45B growth arrest and DNA-damage-inducible, beta
GOLM1 golgi membrane protein 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HYOU1 hypoxia up-regulated 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KRT7 keratin 7, type II
LDLR low density lipoprotein receptor
LUM lumican
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MATN2 matrilin 2
MFAP5 microfibrillar associated protein 5
MXRA5 matrix-remodelling associated 5
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
PAIP1 poly(A) binding protein interacting protein 1
PSAP prosaposin
PTCH1 patched 1
SCGB2A2 secretoglobin, family 2A, member 2
SCN3A sodium channel, voltage gated, type III alpha subunit
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SGCE sarcoglycan, epsilon
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SMCO4 single-pass membrane protein with coiled-coil domains 4
SPINK1 serine peptidase inhibitor, Kazal type 1
TACSTD2 tumor-associated calcium signal transducer 2
TFF3 trefoil factor 3 (intestinal)
TOP2A topoisomerase (DNA) II alpha 170kDa
TUFT1 tuftelin 1
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
VLDLR very low density lipoprotein receptor
ZCCHC24 zinc finger, CCHC domain containing 24