BRD-K76401790_JNK-IN-5A_A549_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

61 genes differentially expressed following the BRD-K76401790_JNK-IN-5A_A549_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
ANXA3 annexin A3
AXL AXL receptor tyrosine kinase
CAV1 caveolin 1, caveolae protein, 22kDa
CLDN3 claudin 3
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DLC1 DLC1 Rho GTPase activating protein
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOSL1 FOS-like antigen 1
HBEGF heparin-binding EGF-like growth factor
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
KIF20A kinesin family member 20A
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
LDLR low density lipoprotein receptor
MSLN mesothelin
RPS11 ribosomal protein S11
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TUBA1A tubulin, alpha 1a

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAMBI BMP and activin membrane-bound inhibitor
C1S complement component 1, s subcomponent
C8ORF4 chromosome 8 open reading frame 4
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF5A eukaryotic translation initiation factor 5A
GCLC glutamate-cysteine ligase, catalytic subunit
IFI44L interferon-induced protein 44-like
IGFBP3 insulin-like growth factor binding protein 3
MMP12 matrix metallopeptidase 12
MXRA5 matrix-remodelling associated 5
NET1 neuroepithelial cell transforming 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NREP neuronal regeneration related protein
PPIF peptidylprolyl isomerase F
RHOBTB1 Rho-related BTB domain containing 1
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRM2 ribonucleotide reductase M2
TMEM14A transmembrane protein 14A
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TOPBP1 topoisomerase (DNA) II binding protein 1
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
VAV3 vav 3 guanine nucleotide exchange factor
VCAN versican