BRD-K76401790_JNK-IN-5A_A549_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

89 genes differentially expressed following the BRD-K76401790_JNK-IN-5A_A549_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
AMOTL2 angiomotin like 2
ANPEP alanyl (membrane) aminopeptidase
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
CAV1 caveolin 1, caveolae protein, 22kDa
CCL2 chemokine (C-C motif) ligand 2
CD44 CD44 molecule (Indian blood group)
CDC20 cell division cycle 20
COL6A2 collagen, type VI, alpha 2
CTGF connective tissue growth factor
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCR4 chemokine (C-X-C motif) receptor 4
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
EIF5B eukaryotic translation initiation factor 5B
EPAS1 endothelial PAS domain protein 1
FABP4 fatty acid binding protein 4, adipocyte
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FNBP1 formin binding protein 1
FOSL1 FOS-like antigen 1
FSTL1 follistatin-like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GAS6 growth arrest-specific 6
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
H2BFS H2B histone family, member S (pseudogene)
HBEGF heparin-binding EGF-like growth factor
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
IL32 interleukin 32
KDM3A lysine (K)-specific demethylase 3A
LAMC2 laminin, gamma 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MSLN mesothelin
OLFM4 olfactomedin 4
PMM2 phosphomannomutase 2
PTRF polymerase I and transcript release factor
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
WT1 Wilms tumor 1

decreased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
AGR2 anterior gradient 2
AKR1C1 aldo-keto reductase family 1, member C1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
BAMBI BMP and activin membrane-bound inhibitor
CDK1 cyclin-dependent kinase 1
CLU clusterin
CPD carboxypeptidase D
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL10 chemokine (C-X-C motif) ligand 10
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF5A eukaryotic translation initiation factor 5A
ENO2 enolase 2 (gamma, neuronal)
FOLR1 folate receptor 1 (adult)
GPX2 glutathione peroxidase 2
HSPA1A heat shock 70kDa protein 1A
IFI44L interferon-induced protein 44-like
LXN latexin
MDK midkine (neurite growth-promoting factor 2)
NAMPT nicotinamide phosphoribosyltransferase
NET1 neuroepithelial cell transforming 1
NREP neuronal regeneration related protein
NTS neurotensin
PRIM1 primase, DNA, polypeptide 1 (49kDa)
RAP1GAP RAP1 GTPase activating protein
RFC2 replication factor C (activator 1) 2, 40kDa
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPA3 replication protein A3, 14kDa
RRM2 ribonucleotide reductase M2
STAT1 signal transducer and activator of transcription 1, 91kDa
SYNE2 spectrin repeat containing, nuclear envelope 2
TESC tescalcin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TOP2A topoisomerase (DNA) II alpha 170kDa
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAV3 vav 3 guanine nucleotide exchange factor
ZWINT ZW10 interacting kinetochore protein