BRD-K76401790_JNK-IN-5A_A375_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

176 genes differentially expressed following the BRD-K76401790_JNK-IN-5A_A375_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADRB2 adrenoceptor beta 2, surface
AKAP8L A kinase (PRKA) anchor protein 8-like
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
AXIN1 axin 1
BMP2 bone morphogenetic protein 2
CASP1 caspase 1, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCND1 cyclin D1
CD14 CD14 molecule
CD47 CD47 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CERS6 ceramide synthase 6
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLGN calmegin
COCH cochlin
CSRP1 cysteine and glycine-rich protein 1
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP1 dual specificity phosphatase 1
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EGR1 early growth response 1
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FHL2 four and a half LIM domains 2
FJX1 four jointed box 1 (Drosophila)
FLNA filamin A, alpha
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GAL galanin/GMAP prepropeptide
GAS6 growth arrest-specific 6
H2BFS H2B histone family, member S (pseudogene)
HACD1 3-hydroxyacyl-CoA dehydratase 1
HBEGF heparin-binding EGF-like growth factor
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HIST1H2BF histone cluster 1, H2bf
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HSPA4L heat shock 70kDa protein 4-like
IER5 immediate early response 5
INSM1 insulinoma-associated 1
ISOC1 isochorismatase domain containing 1
JUND jun D proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLHL21 kelch-like family member 21
KLK10 kallikrein-related peptidase 10
KRT17 keratin 17, type I
LAMB3 laminin, beta 3
LMO3 LIM domain only 3 (rhombotin-like 2)
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP9 matrix metallopeptidase 9
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT2A metallothionein 2A
MYC v-myc avian myelocytomatosis viral oncogene homolog
NELL2 NEL-like 2 (chicken)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A3 nuclear receptor subfamily 4, group A, member 3
OXSR1 oxidative stress responsive 1
PAWR PRKC, apoptosis, WT1, regulator
PECR peroxisomal trans-2-enoyl-CoA reductase
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PODXL podocalyxin-like
RASIP1 Ras interacting protein 1
RBP4 retinol binding protein 4, plasma
RGS2 regulator of G-protein signaling 2
RND3 Rho family GTPase 3
S100A2 S100 calcium binding protein A2
SCD5 stearoyl-CoA desaturase 5
SESN1 sestrin 1
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SOCS2 suppressor of cytokine signaling 2
STK26 serine/threonine protein kinase 26
TARP TCR gamma alternate reading frame protein
TPM1 tropomyosin 1 (alpha)
ZW10 zw10 kinetochore protein

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDOA aldolase A, fructose-bisphosphate
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ASPH aspartate beta-hydroxylase
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CA12 carbonic anhydrase XII
CCNF cyclin F
CD58 CD58 molecule
CDK1 cyclin-dependent kinase 1
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
COL9A3 collagen, type IX, alpha 3
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPYSL3 dihydropyrimidinase-like 3
DYNLT3 dynein, light chain, Tctex-type 3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB3 erb-b2 receptor tyrosine kinase 3
ETV1 ets variant 1
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FOXG1 forkhead box G1
FUCA1 fucosidase, alpha-L- 1, tissue
FZD7 frizzled class receptor 7
GAS7 growth arrest-specific 7
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GSTT1 glutathione S-transferase theta 1
HEATR1 HEAT repeat containing 1
HK2 hexokinase 2
HOPX HOP homeobox
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSPA1A heat shock 70kDa protein 1A
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IGFBP4 insulin-like growth factor binding protein 4
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
LAMB1 laminin, beta 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAGED1 melanoma antigen family D1
MARCKSL1 MARCKS-like 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NES nestin
NQO1 NAD(P)H dehydrogenase, quinone 1
PDE4B phosphodiesterase 4B, cAMP-specific
PGM1 phosphoglucomutase 1
PLIN2 perilipin 2
PLP1 proteolipid protein 1
PPAP2C phosphatidic acid phosphatase type 2C
PPIC peptidylprolyl isomerase C (cyclophilin C)
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
SCNN1B sodium channel, non voltage gated 1 beta subunit
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFRP1 secreted frizzled-related protein 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNX1 sorting nexin 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPRR3 small proline-rich protein 3
STK17A serine/threonine kinase 17a
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TF transferrin
THBS2 thrombospondin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM2 transmembrane protein 2
TNIK TRAF2 and NCK interacting kinase
TOP2A topoisomerase (DNA) II alpha 170kDa
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UGP2 UDP-glucose pyrophosphorylase 2
VCAN versican
VIM vimentin
WNT5A wingless-type MMTV integration site family, member 5A
WWTR1 WW domain containing transcription regulator 1
ZCCHC24 zinc finger, CCHC domain containing 24