BRD-K76401790_JNK-IN-5A_A375_24_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

179 genes differentially expressed following the BRD-K76401790_JNK-IN-5A_A375_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTN1 actinin, alpha 1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL14 ADP-ribosylation factor-like 14
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
BTG2 BTG family, member 2
CA2 carbonic anhydrase II
CCND2 cyclin D2
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLGN calmegin
CXCL13 chemokine (C-X-C motif) ligand 13
CYR61 cysteine-rich, angiogenic inducer, 61
DACH1 dachshund family transcription factor 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DHRS2 dehydrogenase/reductase (SDR family) member 2
DUSP14 dual specificity phosphatase 14
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ESR1 estrogen receptor 1
FAS Fas cell surface death receptor
FCMR Fc fragment of IgM receptor
FDXR ferredoxin reductase
FGFR2 fibroblast growth factor receptor 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA3 GATA binding protein 3
GDF15 growth differentiation factor 15
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRWD1 glutamate-rich WD repeat containing 1
H2BFS H2B histone family, member S (pseudogene)
HBEGF heparin-binding EGF-like growth factor
HHEX hematopoietically expressed homeobox
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H4H histone cluster 1, H4h
HMOX1 heme oxygenase 1
HSPA4L heat shock 70kDa protein 4-like
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGHM immunoglobulin heavy constant mu
KCTD5 potassium channel tetramerization domain containing 5
KLF4 Kruppel-like factor 4 (gut)
KRT14 keratin 14, type I
KRT17 keratin 17, type I
LAMA3 laminin, alpha 3
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
MCL1 myeloid cell leukemia 1
MMP9 matrix metallopeptidase 9
MOK MOK protein kinase
MTSS1 metastasis suppressor 1
NCAM1 neural cell adhesion molecule 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPR1 nuclear protein, transcriptional regulator, 1
PALLD palladin, cytoskeletal associated protein
PEG3 paternally expressed 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIH1D1 PIH1 domain containing 1
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PROM1 prominin 1
REEP1 receptor accessory protein 1
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RIOK3 RIO kinase 3
S100P S100 calcium binding protein P
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SESN1 sestrin 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SPON1 spondin 1, extracellular matrix protein
TFF1 trefoil factor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TOB1 transducer of ERBB2, 1
TSC22D3 TSC22 domain family, member 3
VDAC1 voltage-dependent anion channel 1
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AMACR alpha-methylacyl-CoA racemase
ANXA1 annexin A1
AQP3 aquaporin 3 (Gill blood group)
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BPIFA1 BPI fold containing family A, member 1
CD58 CD58 molecule
CDK1 cyclin-dependent kinase 1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CECR1 cat eye syndrome chromosome region, candidate 1
CEMIP cell migration inducing protein, hyaluronan binding
CFI complement factor I
CHEK2 checkpoint kinase 2
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A1 collagen, type V, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A3 collagen, type VI, alpha 3
CST1 cystatin SN
DPYD dihydropyrimidine dehydrogenase
DPYSL3 dihydropyrimidinase-like 3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB3 erb-b2 receptor tyrosine kinase 3
FSTL1 follistatin-like 1
GLS glutaminase
GNAS GNAS complex locus
GPX2 glutathione peroxidase 2
HMGA2 high mobility group AT-hook 2
HMGB3 high mobility group box 3
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGFBP5 insulin-like growth factor binding protein 5
IGFBP6 insulin-like growth factor binding protein 6
IGFBP7 insulin-like growth factor binding protein 7
IL1R1 interleukin 1 receptor, type I
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IPO13 importin 13
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LPAR1 lysophosphatidic acid receptor 1
LTBP1 latent transforming growth factor beta binding protein 1
MDH1 malate dehydrogenase 1, NAD (soluble)
MELK maternal embryonic leucine zipper kinase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NREP neuronal regeneration related protein
NRP1 neuropilin 1
PCYOX1L prenylcysteine oxidase 1 like
PGM1 phosphoglucomutase 1
PPAP2C phosphatidic acid phosphatase type 2C
PPIC peptidylprolyl isomerase C (cyclophilin C)
RGS17 regulator of G-protein signaling 17
RHOBTB1 Rho-related BTB domain containing 1
S100A7 S100 calcium binding protein A7
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPRR3 small proline-rich protein 3
SPTSSA serine palmitoyltransferase, small subunit A
SRPX2 sushi-repeat containing protein, X-linked 2
TF transferrin
TOP2A topoisomerase (DNA) II alpha 170kDa
TUBB4B tubulin, beta 4B class IVb
UBE2C ubiquitin-conjugating enzyme E2C
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WFDC2 WAP four-disulfide core domain 2
WWTR1 WW domain containing transcription regulator 1