BRD-K76236182_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

174 genes differentially expressed following the BRD-K76236182_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDOC aldolase C, fructose-bisphosphate
ANXA4 annexin A4
BASP1 brain abundant, membrane attached signal protein 1
C3 complement component 3
CA12 carbonic anhydrase XII
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPG capping protein (actin filament), gelsolin-like
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFB complement factor B
CFD complement factor D (adipsin)
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CLCN3 chloride channel, voltage-sensitive 3
COL4A5 collagen, type IV, alpha 5
CTSL cathepsin L
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DEFA5 defensin, alpha 5, Paneth cell-specific
DHRS7 dehydrogenase/reductase (SDR family) member 7
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPYSL3 dihydropyrimidinase-like 3
DST dystonin
DTX4 deltex 4, E3 ubiquitin ligase
DUSP4 dual specificity phosphatase 4
ENO2 enolase 2 (gamma, neuronal)
ERBB2 erb-b2 receptor tyrosine kinase 2
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FADS3 fatty acid desaturase 3
FBLN1 fibulin 1
FCGBP Fc fragment of IgG binding protein
FN1 fibronectin 1
FOXO4 forkhead box O4
FSD1 fibronectin type III and SPRY domain containing 1
FZD2 frizzled class receptor 2
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GLRX glutaredoxin (thioltransferase)
GYPC glycophorin C (Gerbich blood group)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IER5 immediate early response 5
IFI16 interferon, gamma-inducible protein 16
IGFBP6 insulin-like growth factor binding protein 6
IL32 interleukin 32
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KRT19 keratin 19, type I
KRT81 keratin 81, type II
L1CAM L1 cell adhesion molecule
LAMB1 laminin, beta 1
LDHB lactate dehydrogenase B
LDLR low density lipoprotein receptor
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3 lectin, galactoside-binding, soluble, 3
LMO3 LIM domain only 3 (rhombotin-like 2)
LOXL2 lysyl oxidase-like 2
LRP4 low density lipoprotein receptor-related protein 4
MAP1B microtubule-associated protein 1B
MMD monocyte to macrophage differentiation-associated
MUC5B mucin 5B, oligomeric mucus/gel-forming
MVP major vault protein
NELL2 NEL-like 2 (chicken)
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
PALLD palladin, cytoskeletal associated protein
PAM peptidylglycine alpha-amidating monooxygenase
PCCA propionyl CoA carboxylase, alpha polypeptide
PFKM phosphofructokinase, muscle
PGM1 phosphoglucomutase 1
PLAU plasminogen activator, urokinase
PLXNA1 plexin A1
PRSS8 protease, serine, 8
PYGL phosphorylase, glycogen, liver
QPCT glutaminyl-peptide cyclotransferase
RAB29 RAB29, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RHOQ ras homolog family member Q
S100A10 S100 calcium binding protein A10
S100A14 S100 calcium binding protein A14
S100A4 S100 calcium binding protein A4
S100A6 S100 calcium binding protein A6
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELENBP1 selenium binding protein 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC22A18 solute carrier family 22, member 18
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SNAI2 snail family zinc finger 2
SOD2 superoxide dismutase 2, mitochondrial
SOX11 SRY (sex determining region Y)-box 11
SOX4 SRY (sex determining region Y)-box 4
SQSTM1 sequestosome 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STC1 stanniocalcin 1
SYBU syntabulin (syntaxin-interacting)
SYNGR3 synaptogyrin 3
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TRAF5 TNF receptor-associated factor 5
TSKU tsukushi, small leucine rich proteoglycan
TUBB2B tubulin, beta 2B class IIb
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VAT1 vesicle amine transport 1
VIM vimentin
WFDC2 WAP four-disulfide core domain 2
WLS wntless Wnt ligand secretion mediator
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
APP amyloid beta (A4) precursor protein
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
ATG3 autophagy related 3
BIRC5 baculoviral IAP repeat containing 5
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CYTL1 cytokine-like 1
DBF4 DBF4 zinc finger
DCXR dicarbonyl/L-xylulose reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
FANCG Fanconi anemia, complementation group G
FOXM1 forkhead box M1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
H2AFX H2A histone family, member X
HIST1H4C histone cluster 1, H4c
HMGB2 high mobility group box 2
ICAM3 intercellular adhesion molecule 3
KIF14 kinesin family member 14
LIG1 ligase I, DNA, ATP-dependent
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MYCBP MYC binding protein
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa
OIP5 Opa interacting protein 5
PBX3 pre-B-cell leukemia homeobox 3
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
POSTN periostin, osteoblast specific factor
PPIF peptidylprolyl isomerase F
RAD51 RAD51 recombinase
RER1 retention in endoplasmic reticulum sorting receptor 1
RFC5 replication factor C (activator 1) 5, 36.5kDa
RNASEH2A ribonuclease H2, subunit A
SMC2 structural maintenance of chromosomes 2
SPRR1A small proline-rich protein 1A
SPRR3 small proline-rich protein 3
THBS1 thrombospondin 1
TMPO thymopoietin
TRIP13 thyroid hormone receptor interactor 13
ZDHHC6 zinc finger, DHHC-type containing 6