BRD-K76236182_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

81 genes differentially expressed following the BRD-K76236182_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AARS alanyl-tRNA synthetase
ACTA2 actin, alpha 2, smooth muscle, aorta
ADM adrenomedullin
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANXA1 annexin A1
ANXA4 annexin A4
ANXA5 annexin A5
APOD apolipoprotein D
CAST calpastatin
CCNA1 cyclin A1
CD36 CD36 molecule (thrombospondin receptor)
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
COL3A1 collagen, type III, alpha 1
ECM1 extracellular matrix protein 1
FN1 fibronectin 1
GBP2 guanylate binding protein 2, interferon-inducible
GLTSCR2 glioma tumor suppressor candidate region gene 2
GUSBP3 glucuronidase, beta pseudogene 3
HDDC2 HD domain containing 2
HMOX1 heme oxygenase 1
HOXB6 homeobox B6
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
IFITM2 interferon induced transmembrane protein 2
ISG20 interferon stimulated exonuclease gene 20kDa
KIFAP3 kinesin-associated protein 3
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT23 keratin 23, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LGALS1 lectin, galactoside-binding, soluble, 1
LOC100505650 uncharacterized LOC100505650
LYZ lysozyme
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MMP11 matrix metallopeptidase 11
MMP7 matrix metallopeptidase 7
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PNKP polynucleotide kinase 3'-phosphatase
PRAME preferentially expressed antigen in melanoma
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
TM4SF1 transmembrane 4 L six family member 1
USP3 ubiquitin specific peptidase 3
WIF1 WNT inhibitory factor 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCNB1 cyclin B1
CDC25A cell division cycle 25A
CLPTM1 cleft lip and palate associated transmembrane protein 1
CXCL13 chemokine (C-X-C motif) ligand 13
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
FAM46A family with sequence similarity 46, member A
GLIPR1 GLI pathogenesis-related 1
HHEX hematopoietically expressed homeobox
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA14 heat shock 70kDa protein 14
HSPA1A heat shock 70kDa protein 1A
HSPB8 heat shock 22kDa protein 8
IGKV1-5 immunoglobulin kappa variable 1-5
MAT2A methionine adenosyltransferase II, alpha
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
PEG10 paternally expressed 10
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLTP phospholipid transfer protein
PPIF peptidylprolyl isomerase F
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PTGES prostaglandin E synthase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SQLE squalene epoxidase
SRSF2 serine/arginine-rich splicing factor 2