BRD-K75999307_NCGC00182357-01_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

123 genes differentially expressed following the BRD-K75999307_NCGC00182357-01_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
CA12 carbonic anhydrase XII
CADM1 cell adhesion molecule 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CES1 carboxylesterase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CTSB cathepsin B
DDIT4 DNA-damage-inducible transcript 4
DENND2D DENN/MADD domain containing 2D
DIO2 deiodinase, iodothyronine, type II
DMBT1 deleted in malignant brain tumors 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP5 dual specificity phosphatase 5
F3 coagulation factor III (thromboplastin, tissue factor)
FGFBP1 fibroblast growth factor binding protein 1
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
FXYD3 FXYD domain containing ion transport regulator 3
G6PD glucose-6-phosphate dehydrogenase
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GLUL glutamate-ammonia ligase
GPX2 glutathione peroxidase 2
HCAR3 hydroxycarboxylic acid receptor 3
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGKC immunoglobulin kappa constant
IL1R2 interleukin 1 receptor, type II
IL1RN interleukin 1 receptor antagonist
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KYNU kynureninase
LMO4 LIM domain only 4
LRP10 low density lipoprotein receptor-related protein 10
LY6D lymphocyte antigen 6 complex, locus D
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NAMPT nicotinamide phosphoribosyltransferase
NDNF neuron-derived neurotrophic factor
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NQO1 NAD(P)H dehydrogenase, quinone 1
NR0B1 nuclear receptor subfamily 0, group B, member 1
PGD phosphogluconate dehydrogenase
PGF placental growth factor
PI3 peptidase inhibitor 3, skin-derived
PIR pirin (iron-binding nuclear protein)
PKP1 plakophilin 1
PLBD1 phospholipase B domain containing 1
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SFTPB surfactant protein B
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SPRR2B small proline-rich protein 2B
SPRR3 small proline-rich protein 3
SQSTM1 sequestosome 1
TALDO1 transaldolase 1
TM4SF1 transmembrane 4 L six family member 1
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB3 tribbles pseudokinase 3
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
AHR aryl hydrocarbon receptor
ASRGL1 asparaginase like 1
BEX1 brain expressed, X-linked 1
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CHL1 cell adhesion molecule L1-like
CLIC5 chloride intracellular channel 5
CTGF connective tissue growth factor
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYR61 cysteine-rich, angiogenic inducer, 61
DHCR24 24-dehydrocholesterol reductase
EREG epiregulin
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
KIAA1033 KIAA1033
LEPR leptin receptor
LOC100505650 uncharacterized LOC100505650
LRRC17 leucine rich repeat containing 17
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NPY1R neuropeptide Y receptor Y1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PLAGL1 pleiomorphic adenoma gene-like 1
PNMA2 paraneoplastic Ma antigen 2
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRUNE2 prune homolog 2 (Drosophila)
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PXDN peroxidasin
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RTN1 reticulon 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SRSF6 serine/arginine-rich splicing factor 6
SST somatostatin
STXBP2 syntaxin binding protein 2
TFPI2 tissue factor pathway inhibitor 2
TFRC transferrin receptor
TLE4 transducin-like enhancer of split 4
TNS1 tensin 1
VCAN versican