BRD-K75641298_METOCLOPRAMIDE HYDROCHLORIDE_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

198 genes differentially expressed following the BRD-K75641298_METOCLOPRAMIDE HYDROCHLORIDE_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADAT1 adenosine deaminase, tRNA-specific 1
ANPEP alanyl (membrane) aminopeptidase
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL2L1 BCL2-like 1
CA1 carbonic anhydrase I
CARD10 caspase recruitment domain family, member 10
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CLIC5 chloride intracellular channel 5
CPM carboxypeptidase M
CST1 cystatin SN
CTTN cortactin
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDIT4 DNA-damage-inducible transcript 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DUSP4 dual specificity phosphatase 4
EDN3 endothelin 3
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
F3 coagulation factor III (thromboplastin, tissue factor)
FABP4 fatty acid binding protein 4, adipocyte
FAM189A2 family with sequence similarity 189, member A2
FXYD3 FXYD domain containing ion transport regulator 3
GLRX glutaredoxin (thioltransferase)
GOLT1B golgi transport 1B
GREB1 growth regulation by estrogen in breast cancer 1
HBD hemoglobin, delta
HGD homogentisate 1,2-dioxygenase
HOMER2 homer scaffolding protein 2
HSPA2 heat shock 70kDa protein 2
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGF1R insulin-like growth factor 1 receptor
IGFBP6 insulin-like growth factor binding protein 6
IL1R1 interleukin 1 receptor, type I
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
KIAA1324 KIAA1324
KLK2 kallikrein-related peptidase 2
LDLR low density lipoprotein receptor
LOC100505650 uncharacterized LOC100505650
LXN latexin
MFAP5 microfibrillar associated protein 5
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MME membrane metallo-endopeptidase
MPO myeloperoxidase
MSMB microseminoprotein, beta-
MT1M metallothionein 1M
MYO5C myosin VC
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NT5E 5'-nucleotidase, ecto (CD73)
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OSBPL10 oxysterol binding protein-like 10
PLAT plasminogen activator, tissue
PSENEN presenilin enhancer gamma secretase subunit
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
QPCT glutaminyl-peptide cyclotransferase
RAP1GAP RAP1 GTPase activating protein
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF167 ring finger protein 167
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RTN1 reticulon 1
SCGB2A1 secretoglobin, family 2A, member 1
SFRP1 secreted frizzled-related protein 1
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPDEF SAM pointed domain containing ETS transcription factor
ST18 suppression of tumorigenicity 18, zinc finger
STXBP1 syntaxin binding protein 1
STXBP2 syntaxin binding protein 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFPI2 tissue factor pathway inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMC5 transmembrane channel-like 5
TMPRSS3 transmembrane protease, serine 3
TP53I3 tumor protein p53 inducible protein 3
TUBB2A tubulin, beta 2A class IIa
VTCN1 V-set domain containing T cell activation inhibitor 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
AKAP7 A kinase (PRKA) anchor protein 7
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
BARD1 BRCA1 associated RING domain 1
BRCA1 breast cancer 1, early onset
C1QA complement component 1, q subcomponent, A chain
CACYBP calcyclin binding protein
CCDC59 coiled-coil domain containing 59
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCNE2 cyclin E2
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CHEK2 checkpoint kinase 2
CIT citron rho-interacting serine/threonine kinase
DCK deoxycytidine kinase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAR2 fatty acyl CoA reductase 2
FBXO11 F-box protein 11
FBXO5 F-box protein 5
FRZB frizzled-related protein
GAS1 growth arrest-specific 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
HELLS helicase, lymphoid-specific
HES1 hes family bHLH transcription factor 1
HJURP Holliday junction recognition protein
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXC6 homeobox C6
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IGL immunoglobulin lambda locus
ITGB3BP integrin beta 3 binding protein (beta3-endonexin)
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
LAMP5 lysosomal-associated membrane protein family, member 5
LDHB lactate dehydrogenase B
LGALS4 lectin, galactoside-binding, soluble, 4
LIG1 ligase I, DNA, ATP-dependent
LMO3 LIM domain only 3 (rhombotin-like 2)
LYZ lysozyme
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MMP9 matrix metallopeptidase 9
MTA1 metastasis associated 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NASP nuclear autoantigenic sperm protein (histone-binding)
NCAPG non-SMC condensin I complex, subunit G
NMU neuromedin U
NUSAP1 nucleolar and spindle associated protein 1
OXCT1 3-oxoacid CoA transferase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPAT phosphoribosyl pyrophosphate amidotransferase
PRC1 protein regulator of cytokinesis 1
PRMT1 protein arginine methyltransferase 1
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PSIP1 PC4 and SFRS1 interacting protein 1
PTTG1 pituitary tumor-transforming 1
RAD51AP1 RAD51 associated protein 1
RGS2 regulator of G-protein signaling 2
RNASEH2A ribonuclease H2, subunit A
RPA3 replication protein A3, 14kDa
RRM2 ribonucleotide reductase M2
RRP1B ribosomal RNA processing 1B
S100P S100 calcium binding protein P
SCARB1 scavenger receptor class B, member 1
SESN1 sestrin 1
SHCBP1 SHC SH2-domain binding protein 1
SPC25 SPC25, NDC80 kinetochore complex component
ST7 suppression of tumorigenicity 7
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACC3 transforming, acidic coiled-coil containing protein 3
TMEM176B transmembrane protein 176B
TMEM38B transmembrane protein 38B
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIB1 tribbles pseudokinase 1
TTK TTK protein kinase
TUBA4A tubulin, alpha 4a
TXN thioredoxin
U2SURP U2 snRNP-associated SURP domain containing
UBE2S ubiquitin-conjugating enzyme E2S
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
VCAM1 vascular cell adhesion molecule 1