BRD-K75477256_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

134 genes differentially expressed following the BRD-K75477256_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA3 annexin A3
APOLD1 apolipoprotein L domain containing 1
ASPN asporin
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
CAV2 caveolin 2
CD9 CD9 molecule
CFH complement factor H
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CLDN4 claudin 4
COG5 component of oligomeric golgi complex 5
CRISP3 cysteine-rich secretory protein 3
CXCL11 chemokine (C-X-C motif) ligand 11
CYR61 cysteine-rich, angiogenic inducer, 61
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EGR3 early growth response 3
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EMP1 epithelial membrane protein 1
EPCAM epithelial cell adhesion molecule
EPHA2 EPH receptor A2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM107A family with sequence similarity 107, member A
FHL2 four and a half LIM domains 2
FMO2 flavin containing monooxygenase 2 (non-functional)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
HBEGF heparin-binding EGF-like growth factor
HCAR3 hydroxycarboxylic acid receptor 3
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HIST1H2BC histone cluster 1, H2bc
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER3 immediate early response 3
IGFBP5 insulin-like growth factor binding protein 5
IL1RL1 interleukin 1 receptor-like 1
JUNB jun B proto-oncogene
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBNL2 muscleblind-like splicing regulator 2
MME membrane metallo-endopeptidase
MT1X metallothionein 1X
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NR4A1 nuclear receptor subfamily 4, group A, member 1
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM4 PDZ and LIM domain 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
POSTN periostin, osteoblast specific factor
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RCAN1 regulator of calcineurin 1
RGCC regulator of cell cycle
RND3 Rho family GTPase 3
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIK1 salt-inducible kinase 1
SMAD3 SMAD family member 3
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
STC2 stanniocalcin 2
TGFA transforming growth factor, alpha
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
VEGFA vascular endothelial growth factor A
WEE1 WEE1 G2 checkpoint kinase
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AGR2 anterior gradient 2
AHR aryl hydrocarbon receptor
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BASP1 brain abundant, membrane attached signal protein 1
BRCA1 breast cancer 1, early onset
CAST calpastatin
CDCA4 cell division cycle associated 4
CHGB chromogranin B
COL7A1 collagen, type VII, alpha 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CTSZ cathepsin Z
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EIF5A eukaryotic translation initiation factor 5A
FLRT2 fibronectin leucine rich transmembrane protein 2
FLRT3 fibronectin leucine rich transmembrane protein 3
GJA1 gap junction protein, alpha 1, 43kDa
HSPA8 heat shock 70kDa protein 8
IGHD immunoglobulin heavy constant delta
IGKV1-5 immunoglobulin kappa variable 1-5
IGLJ3 immunoglobulin lambda joining 3
IRS2 insulin receptor substrate 2
JCHAIN joining chain of multimeric IgA and IgM
KCTD12 potassium channel tetramerization domain containing 12
KIAA0907 KIAA0907
KIF18B kinesin family member 18B
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAP2K6 mitogen-activated protein kinase kinase 6
MN1 meningioma (disrupted in balanced translocation) 1
MXRA5 matrix-remodelling associated 5
NEFH neurofilament, heavy polypeptide
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBX1 pre-B-cell leukemia homeobox 1
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
RHOBTB3 Rho-related BTB domain containing 3
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPS11 ribosomal protein S11
SELL selectin L
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPON1 spondin 1, extracellular matrix protein
SRC SRC proto-oncogene, non-receptor tyrosine kinase
THAP11 THAP domain containing 11
TLR4 toll-like receptor 4
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX3 TOX high mobility group box family member 3
TPBG trophoblast glycoprotein
TRAK2 trafficking protein, kinesin binding 2
TSPAN13 tetraspanin 13
TSPYL5 TSPY-like 5
VCAN versican