BRD-K75308990_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

49 genes differentially expressed following the BRD-K75308990_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
BEX1 brain expressed, X-linked 1
DDIT4 DNA-damage-inducible transcript 4
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
IER5 immediate early response 5
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLCB4 phospholipase C, beta 4
PLK2 polo-like kinase 2
PODXL podocalyxin-like
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
RND3 Rho family GTPase 3
SLC26A2 solute carrier family 26 (anion exchanger), member 2

decreased expression

Symbol Name
AIM1 absent in melanoma 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
CCNA2 cyclin A2
CDK1 cyclin-dependent kinase 1
CFH complement factor H
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
FANCI Fanconi anemia, complementation group I
HIST1H4C histone cluster 1, H4c
HLF hepatic leukemia factor
IGL immunoglobulin lambda locus
KIF2C kinesin family member 2C
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MELK maternal embryonic leucine zipper kinase
MEOX2 mesenchyme homeobox 2
MSMO1 methylsterol monooxygenase 1
PBK PDZ binding kinase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PRC1 protein regulator of cytokinesis 1
RAD51AP1 RAD51 associated protein 1
RNASE4 ribonuclease, RNase A family, 4
RRM2 ribonucleotide reductase M2
SPP1 secreted phosphoprotein 1
SQLE squalene epoxidase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
UBE2C ubiquitin-conjugating enzyme E2C
WEE1 WEE1 G2 checkpoint kinase
ZWINT ZW10 interacting kinetochore protein