BRD-K75081836_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

303 genes differentially expressed following the BRD-K75081836_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACO1 aconitase 1, soluble
ACOT7 acyl-CoA thioesterase 7
ADGRE5 adhesion G protein-coupled receptor E5
AGFG2 ArfGAP with FG repeats 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDOC aldolase C, fructose-bisphosphate
ANOS1 anosmin 1
ANXA6 annexin A6
ASMTL acetylserotonin O-methyltransferase-like
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BLVRA biliverdin reductase A
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BPGM 2,3-bisphosphoglycerate mutase
C1QTNF3 C1q and tumor necrosis factor related protein 3
CA1 carbonic anhydrase I
CALCOCO2 calcium binding and coiled-coil domain 2
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CAPG capping protein (actin filament), gelsolin-like
CCND3 cyclin D3
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHI3L2 chitinase 3-like 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKB creatine kinase, brain
COG5 component of oligomeric golgi complex 5
CORO1A coronin, actin binding protein, 1A
COTL1 coactosin-like F-actin binding protein 1
CP ceruloplasmin (ferroxidase)
CREG1 cellular repressor of E1A-stimulated genes 1
CTR9 CTR9, Paf1/RNA polymerase II complex component
CTSA cathepsin A
DAPK1 death-associated protein kinase 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DHCR7 7-dehydrocholesterol reductase
DMPK dystrophia myotonica-protein kinase
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EPAS1 endothelial PAS domain protein 1
EPB41L2 erythrocyte membrane protein band 4.1-like 2
ETHE1 ethylmalonic encephalopathy 1
FAM117A family with sequence similarity 117, member A
FGF9 fibroblast growth factor 9
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FOXO4 forkhead box O4
FUCA1 fucosidase, alpha-L- 1, tissue
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
GLRX glutaredoxin (thioltransferase)
GM2A GM2 ganglioside activator
GMCL1 germ cell-less, spermatogenesis associated 1
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNS glucosamine (N-acetyl)-6-sulfatase
GRK5 G protein-coupled receptor kinase 5
GRN granulin
GSDMB gasdermin B
GSN gelsolin
GSTA4 glutathione S-transferase alpha 4
GSTP1 glutathione S-transferase pi 1
HLA-B major histocompatibility complex, class I, B
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP5 insulin-like growth factor binding protein 5
IL2RG interleukin 2 receptor, gamma
IL32 interleukin 32
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INSIG1 insulin induced gene 1
ISG15 ISG15 ubiquitin-like modifier
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGA6 integrin, alpha 6
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITM2A integral membrane protein 2A
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3
KCTD5 potassium channel tetramerization domain containing 5
KLHL24 kelch-like family member 24
LCK LCK proto-oncogene, Src family tyrosine kinase
LGMN legumain
LIMA1 LIM domain and actin binding 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LPCAT1 lysophosphatidylcholine acyltransferase 1
LPIN1 lipin 1
LPXN leupaxin
LTA4H leukotriene A4 hydrolase
MAGEB2 melanoma antigen family B2
MAN2A1 mannosidase, alpha, class 2A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MAPT microtubule-associated protein tau
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MGST3 microsomal glutathione S-transferase 3
MID1 midline 1
MLEC malectin
MLF1 myeloid leukemia factor 1
MSN moesin
MSX1 msh homeobox 1
MT1X metallothionein 1X
MVP major vault protein
MXRA7 matrix-remodelling associated 7
NCAM1 neural cell adhesion molecule 1
NDRG1 N-myc downstream regulated 1
NLRP2 NLR family, pyrin domain containing 2
NMT2 N-myristoyltransferase 2
NOSIP nitric oxide synthase interacting protein
NPC1 Niemann-Pick disease, type C1
NQO2 NAD(P)H dehydrogenase, quinone 2
NT5DC2 5'-nucleotidase domain containing 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEG10 paternally expressed 10
PHYH phytanoyl-CoA 2-hydroxylase
PLA2G15 phospholipase A2, group XV
PNMA2 paraneoplastic Ma antigen 2
POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa
POR P450 (cytochrome) oxidoreductase
PRAME preferentially expressed antigen in melanoma
PRKCB protein kinase C, beta
PRSS21 protease, serine, 21 (testisin)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAD9A RAD9 homolog A (S. pombe)
RBP1 retinol binding protein 1, cellular
REEP1 receptor accessory protein 1
RGS10 regulator of G-protein signaling 10
RIOK3 RIO kinase 3
ROGDI rogdi homolog (Drosophila)
RRAS related RAS viral (r-ras) oncogene homolog
RTN2 reticulon 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPT6 septin 6
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SHROOM2 shroom family member 2
SKAP2 src kinase associated phosphoprotein 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC46A3 solute carrier family 46, member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SNX11 sorting nexin 11
SOX11 SRY (sex determining region Y)-box 11
SPTSSA serine palmitoyltransferase, small subunit A
STAB1 stabilin 1
STOM stomatin
STX1A syntaxin 1A (brain)
STXBP1 syntaxin binding protein 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIAM1 T-cell lymphoma invasion and metastasis 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TM7SF2 transmembrane 7 superfamily member 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM41B transmembrane protein 41B
TMSB15A thymosin beta 15a
TNS1 tensin 1
TSPAN12 tetraspanin 12
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VIM vimentin
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ADAM12 ADAM metallopeptidase domain 12
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
AKAP8 A kinase (PRKA) anchor protein 8
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ARGLU1 arginine and glutamate rich 1
ARID1A AT rich interactive domain 1A (SWI-like)
ATF1 activating transcription factor 1
ATF5 activating transcription factor 5
BCAS2 breast carcinoma amplified sequence 2
BEX1 brain expressed, X-linked 1
C2CD5 C2 calcium-dependent domain containing 5
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CCND1 cyclin D1
CD58 CD58 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
COL1A1 collagen, type I, alpha 1
CPE carboxypeptidase E
CREBBP CREB binding protein
CSDE1 cold shock domain containing E1, RNA-binding
CTBP1 C-terminal binding protein 1
CTBP2 C-terminal binding protein 2
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CYB561 cytochrome b561
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DACH1 dachshund family transcription factor 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
ELF1 E74-like factor 1 (ets domain transcription factor)
EREG epiregulin
ESR1 estrogen receptor 1
EXOSC8 exosome component 8
FAM57A family with sequence similarity 57, member A
FHL2 four and a half LIM domains 2
FZD6 frizzled class receptor 6
GABPB1 GA binding protein transcription factor, beta subunit 1
GAS2 growth arrest-specific 2
GATA3 GATA binding protein 3
GPM6B glycoprotein M6B
GPX2 glutathione peroxidase 2
GREB1 growth regulation by estrogen in breast cancer 1
GTSE1 G-2 and S-phase expressed 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGF1R insulin-like growth factor 1 receptor
IRAK1 interleukin-1 receptor-associated kinase 1
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
KCNK1 potassium channel, two pore domain subfamily K, member 1
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
KRT14 keratin 14, type I
KRT19 keratin 19, type I
LAMB1 laminin, beta 1
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MARCKS myristoylated alanine-rich protein kinase C substrate
MECOM MDS1 and EVI1 complex locus
METTL7A methyltransferase like 7A
MLPH melanophilin
MME membrane metallo-endopeptidase
MRPS30 mitochondrial ribosomal protein S30
MSMB microseminoprotein, beta-
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NCOA2 nuclear receptor coactivator 2
NPY1R neuropeptide Y receptor Y1
NR2F6 nuclear receptor subfamily 2, group F, member 6
NRIP1 nuclear receptor interacting protein 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUP50 nucleoporin 50kDa
PARP2 poly (ADP-ribose) polymerase 2
PDGFA platelet-derived growth factor alpha polypeptide
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
PNN pinin, desmosome associated protein
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD)
POSTN periostin, osteoblast specific factor
PPIF peptidylprolyl isomerase F
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PRR7 proline rich 7 (synaptic)
PSCA prostate stem cell antigen
RAB25 RAB25, member RAS oncogene family
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS5 regulator of G-protein signaling 5
RIPK2 receptor-interacting serine-threonine kinase 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SENP6 SUMO1/sentrin specific peptidase 6
SFPQ splicing factor proline/glutamine-rich
SFRP1 secreted frizzled-related protein 1
SLC35F2 solute carrier family 35, member F2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD3 SMAD family member 3
SMNDC1 survival motor neuron domain containing 1
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPON2 spondin 2, extracellular matrix protein
SPRY2 sprouty homolog 2 (Drosophila)
STC2 stanniocalcin 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TBX2 T-box 2
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF1 trefoil factor 1
THBS1 thrombospondin 1
TMPO thymopoietin
TP53 tumor protein p53
TPBG trophoblast glycoprotein
TSKU tsukushi, small leucine rich proteoglycan
TWIST1 twist family bHLH transcription factor 1
UBE2E3 ubiquitin-conjugating enzyme E2E 3
USP22 ubiquitin specific peptidase 22
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
WDR43 WD repeat domain 43
WEE1 WEE1 G2 checkpoint kinase
WWP1 WW domain containing E3 ubiquitin protein ligase 1
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZBTB20 zinc finger and BTB domain containing 20
ZFP36L2 ZFP36 ring finger protein-like 2
ZHX2 zinc fingers and homeoboxes 2
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF217 zinc finger protein 217
ZNF512B zinc finger protein 512B