BRD-K75081836_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

161 genes differentially expressed following the BRD-K75081836_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACAD8 acyl-CoA dehydrogenase family, member 8
ACLY ATP citrate lyase
ACOT7 acyl-CoA thioesterase 7
ALDOC aldolase C, fructose-bisphosphate
APLP2 amyloid beta (A4) precursor-like protein 2
ASMTL acetylserotonin O-methyltransferase-like
ATG2A autophagy related 2A
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CA1 carbonic anhydrase I
CCND3 cyclin D3
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
COG5 component of oligomeric golgi complex 5
CORO1A coronin, actin binding protein, 1A
COTL1 coactosin-like F-actin binding protein 1
CPM carboxypeptidase M
CREG1 cellular repressor of E1A-stimulated genes 1
CTR9 CTR9, Paf1/RNA polymerase II complex component
CTSV cathepsin V
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYTH1 cytohesin 1
DCXR dicarbonyl/L-xylulose reductase
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP6 dual specificity phosphatase 6
EFHD1 EF-hand domain family, member D1
EIF4A3 eukaryotic translation initiation factor 4A3
EIF5A eukaryotic translation initiation factor 5A
ETV5 ets variant 5
FAM117A family with sequence similarity 117, member A
FCHO1 FCH domain only 1
FOXO4 forkhead box O4
FUCA1 fucosidase, alpha-L- 1, tissue
G6PD glucose-6-phosphate dehydrogenase
GADD45B growth arrest and DNA-damage-inducible, beta
GM2A GM2 ganglioside activator
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GRN granulin
GSTP1 glutathione S-transferase pi 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HK1 hexokinase 1
HN1 hematological and neurological expressed 1
HSDL2 hydroxysteroid dehydrogenase like 2
HSPA1A heat shock 70kDa protein 1A
ICAM1 intercellular adhesion molecule 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI6 interferon, alpha-inducible protein 6
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KCTD12 potassium channel tetramerization domain containing 12
LDHB lactate dehydrogenase B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCOLN1 mucolipin 1
MEGF9 multiple EGF-like-domains 9
MT1X metallothionein 1X
NLRP2 NLR family, pyrin domain containing 2
NOSIP nitric oxide synthase interacting protein
NPR3 natriuretic peptide receptor 3
NTS neurotensin
OAT ornithine aminotransferase
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PFKM phosphofructokinase, muscle
PLA2G15 phospholipase A2, group XV
POLB polymerase (DNA directed), beta
PPARD peroxisome proliferator-activated receptor delta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCD protein kinase C, delta
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAD9A RAD9 homolog A (S. pombe)
RIOK3 RIO kinase 3
SEPT6 septin 6
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SKP1 S-phase kinase-associated protein 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STXBP1 syntaxin binding protein 1
SYNGR2 synaptogyrin 2
SYNGR3 synaptogyrin 3
TM7SF2 transmembrane 7 superfamily member 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN13 tetraspanin 13
TUBA4A tubulin, alpha 4a
TUBB3 tubulin, beta 3 class III
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
VIM vimentin

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
ADORA2B adenosine A2b receptor
AKR1C2 aldo-keto reductase family 1, member C2
ALCAM activated leukocyte cell adhesion molecule
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATXN10 ataxin 10
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BID BH3 interacting domain death agonist
BMP4 bone morphogenetic protein 4
BTG1 B-cell translocation gene 1, anti-proliferative
C1ORF106 chromosome 1 open reading frame 106
CASP7 caspase 7, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
DPT dermatopontin
EIF5 eukaryotic translation initiation factor 5
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EPCAM epithelial cell adhesion molecule
EREG epiregulin
EXOSC8 exosome component 8
FAM60A family with sequence similarity 60, member A
FGFR3 fibroblast growth factor receptor 3
FOSL1 FOS-like antigen 1
FRZB frizzled-related protein
GAS2 growth arrest-specific 2
GPNMB glycoprotein (transmembrane) nmb
GPX2 glutathione peroxidase 2
GREM1 gremlin 1, DAN family BMP antagonist
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
KEAP1 kelch-like ECH-associated protein 1
KRT13 keratin 13, type I
KRT15 keratin 15, type I
KRT19 keratin 19, type I
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LPAR6 lysophosphatidic acid receptor 6
LRRC41 leucine rich repeat containing 41
LYZ lysozyme
MARCKS myristoylated alanine-rich protein kinase C substrate
MECOM MDS1 and EVI1 complex locus
MMP9 matrix metallopeptidase 9
MSLN mesothelin
NBN nibrin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFE2L2 nuclear factor, erythroid 2-like 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PROM1 prominin 1
PSCA prostate stem cell antigen
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGCC regulator of cell cycle
S100P S100 calcium binding protein P
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SORBS2 sorbin and SH3 domain containing 2
SPINK1 serine peptidase inhibitor, Kazal type 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
SYBU syntabulin (syntaxin-interacting)
TF transferrin
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TOX3 TOX high mobility group box family member 3
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UFC1 ubiquitin-fold modifier conjugating enzyme 1
USP22 ubiquitin specific peptidase 22
WEE1 WEE1 G2 checkpoint kinase
WTAP Wilms tumor 1 associated protein
ZMYND8 zinc finger, MYND-type containing 8