BRD-K75081836_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

158 genes differentially expressed following the BRD-K75081836_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ALAS1 5'-aminolevulinate synthase 1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANXA6 annexin A6
AQP4 aquaporin 4
ATF3 activating transcription factor 3
BCL6 B-cell CLL/lymphoma 6
CD14 CD14 molecule
CD52 CD52 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
COG5 component of oligomeric golgi complex 5
COL1A1 collagen, type I, alpha 1
CSRP1 cysteine and glycine-rich protein 1
CTSZ cathepsin Z
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL13 chemokine (C-X-C motif) ligand 13
CYBB cytochrome b-245, beta polypeptide
DSTN destrin (actin depolymerizing factor)
EIF5A eukaryotic translation initiation factor 5A
EZR ezrin
FABP4 fatty acid binding protein 4, adipocyte
FADS2 fatty acid desaturase 2
FAM107A family with sequence similarity 107, member A
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FYB FYN binding protein
G6PD glucose-6-phosphate dehydrogenase
GADD45B growth arrest and DNA-damage-inducible, beta
GLRX glutaredoxin (thioltransferase)
GSN gelsolin
HBB hemoglobin, beta
HCLS1 hematopoietic cell-specific Lyn substrate 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSPA1A heat shock 70kDa protein 1A
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI6 interferon, alpha-inducible protein 6
IL32 interleukin 32
IQCG IQ motif containing G
IQGAP2 IQ motif containing GTPase activating protein 2
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JUN jun proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
LAPTM5 lysosomal protein transmembrane 5
LPCAT1 lysophosphatidylcholine acyltransferase 1
LTF lactotransferrin
MAOB monoamine oxidase B
MARCH2 membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
MATN2 matrilin 2
MGST3 microsomal glutathione S-transferase 3
MMP7 matrix metallopeptidase 7
NCF2 neutrophil cytosolic factor 2
NFIL3 nuclear factor, interleukin 3 regulated
NLRP2 NLR family, pyrin domain containing 2
NNAT neuronatin
NOSIP nitric oxide synthase interacting protein
NPR3 natriuretic peptide receptor 3
NQO2 NAD(P)H dehydrogenase, quinone 2
PALLD palladin, cytoskeletal associated protein
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PEA15 phosphoprotein enriched in astrocytes 15
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLA2G15 phospholipase A2, group XV
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RCAN1 regulator of calcineurin 1
REEP1 receptor accessory protein 1
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SELL selectin L
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SNN stannin
SRGN serglycin
SYNM synemin, intermediate filament protein
TFF3 trefoil factor 3 (intestinal)
TLE4 transducin-like enhancer of split 4
TPM2 tropomyosin 2 (beta)
TSPAN13 tetraspanin 13
TUBB2A tubulin, beta 2A class IIa
TXNIP thioredoxin interacting protein
TYROBP TYRO protein tyrosine kinase binding protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VNN1 vanin 1
WFS1 Wolfram syndrome 1 (wolframin)

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ALCAM activated leukocyte cell adhesion molecule
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ATF1 activating transcription factor 1
BEX1 brain expressed, X-linked 1
C2CD5 C2 calcium-dependent domain containing 5
CCND1 cyclin D1
CIAPIN1 cytokine induced apoptosis inhibitor 1
CNIH1 cornichon family AMPA receptor auxiliary protein 1
CPE carboxypeptidase E
DKK1 dickkopf WNT signaling pathway inhibitor 1
EXOSC4 exosome component 4
FAM57A family with sequence similarity 57, member A
FOSL1 FOS-like antigen 1
GNAS GNAS complex locus
GOLGA8A golgin A8 family, member A
GPX2 glutathione peroxidase 2
HEATR1 HEAT repeat containing 1
HMGA2 high mobility group AT-hook 2
IFRD2 interferon-related developmental regulator 2
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
LRRC41 leucine rich repeat containing 41
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MECOM MDS1 and EVI1 complex locus
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MOK MOK protein kinase
MSLN mesothelin
MZT2B mitotic spindle organizing protein 2B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NID1 nidogen 1
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
OBSL1 obscurin-like 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OXA1L oxidase (cytochrome c) assembly 1-like
PDCD2 programmed cell death 2
PDGFC platelet derived growth factor C
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLS3 plastin 3
PPIB peptidylprolyl isomerase B (cyclophilin B)
PRPS2 phosphoribosyl pyrophosphate synthetase 2
REEP5 receptor accessory protein 5
RNPS1 RNA binding protein S1, serine-rich domain
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SPRY2 sprouty homolog 2 (Drosophila)
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM4SF1 transmembrane 4 L six family member 1
TWIST1 twist family bHLH transcription factor 1
USP22 ubiquitin specific peptidase 22
VEGFA vascular endothelial growth factor A
ZMYND11 zinc finger, MYND-type containing 11
ZNF512B zinc finger protein 512B