BRD-K74989018_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

115 genes differentially expressed following the BRD-K74989018_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACD adrenocortical dysplasia homolog (mouse)
ALDOB aldolase B, fructose-bisphosphate
ANPEP alanyl (membrane) aminopeptidase
ANXA1 annexin A1
ASRGL1 asparaginase like 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CADM1 cell adhesion molecule 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHGB chromogranin B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
CLCA1 chloride channel accessory 1
DEFA5 defensin, alpha 5, Paneth cell-specific
DKK3 dickkopf WNT signaling pathway inhibitor 3
EDN3 endothelin 3
EPAS1 endothelial PAS domain protein 1
FBN2 fibrillin 2
FGFR2 fibroblast growth factor receptor 2
GPM6A glycoprotein M6A
HEPH hephaestin
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPA2 heat shock 70kDa protein 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGHM immunoglobulin heavy constant mu
IGLV2-23 immunoglobulin lambda variable 2-23
IL1R2 interleukin 1 receptor, type II
IPO13 importin 13
IQGAP1 IQ motif containing GTPase activating protein 1
ISG15 ISG15 ubiquitin-like modifier
ITM2C integral membrane protein 2C
KRT20 keratin 20, type I
KRT23 keratin 23, type I
LYN LYN proto-oncogene, Src family tyrosine kinase
MEIS2 Meis homeobox 2
MMP7 matrix metallopeptidase 7
MX1 MX dynamin-like GTPase 1
NES nestin
OLFM4 olfactomedin 4
PCDH7 protocadherin 7
RGCC regulator of cell cycle
RNF24 ring finger protein 24
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
S100P S100 calcium binding protein P
SFRP1 secreted frizzled-related protein 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TGFA transforming growth factor, alpha
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRD T cell receptor delta locus
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
UBE2J1 ubiquitin-conjugating enzyme E2, J1
VEGFA vascular endothelial growth factor A
WSB1 WD repeat and SOCS box containing 1

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADI1 acireductone dioxygenase 1
AHR aryl hydrocarbon receptor
ANXA7 annexin A7
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ATF1 activating transcription factor 1
ATMIN ATM interactor
BACE2 beta-site APP-cleaving enzyme 2
BST2 bone marrow stromal cell antigen 2
C2CD5 C2 calcium-dependent domain containing 5
C3 complement component 3
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CCDC47 coiled-coil domain containing 47
CHPT1 choline phosphotransferase 1
CLU clusterin
CTTN cortactin
CXCL12 chemokine (C-X-C motif) ligand 12
CYBB cytochrome b-245, beta polypeptide
DCLK1 doublecortin-like kinase 1
DLD dihydrolipoamide dehydrogenase
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
EGR3 early growth response 3
ERBB3 erb-b2 receptor tyrosine kinase 3
ESR1 estrogen receptor 1
FAM134B family with sequence similarity 134, member B
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
HDGFRP3 hepatoma-derived growth factor, related protein 3
HPRT1 hypoxanthine phosphoribosyltransferase 1
IFI27 interferon, alpha-inducible protein 27
IL6ST interleukin 6 signal transducer
KIF14 kinesin family member 14
KLF2 Kruppel-like factor 2
KRT17 keratin 17, type I
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAPTM4B lysosomal protein transmembrane 4 beta
LXN latexin
LYPLA1 lysophospholipase I
NNMT nicotinamide N-methyltransferase
NOTCH2 notch 2
NPY neuropeptide Y
NRIP1 nuclear receptor interacting protein 1
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
PXDN peroxidasin
RAD23B RAD23 homolog B (S. cerevisiae)
RCN2 reticulocalbin 2, EF-hand calcium binding domain
REEP5 receptor accessory protein 5
RPS11 ribosomal protein S11
S100A13 S100 calcium binding protein A13
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SRSF6 serine/arginine-rich splicing factor 6
TFPI2 tissue factor pathway inhibitor 2
TUSC3 tumor suppressor candidate 3
UBE3C ubiquitin protein ligase E3C
UGCG UDP-glucose ceramide glucosyltransferase
USP22 ubiquitin specific peptidase 22
WWP1 WW domain containing E3 ubiquitin protein ligase 1
XPO7 exportin 7